Gazzi, Arianna ORCID: 0000-0002-4142-485X, Fusco, Laura ORCID: 0000-0003-1418-507X, Orecchioni, Marco, Ferrari, Silvia, Franzoni, Giulia ORCID: 0000-0003-0987-3863, Yan, J. Stephen, Rieckher, Matthias, Peng, Guotao, Lucherelli, Matteo Andrea ORCID: 0000-0003-1055-3269, Anna Vacchi, Isabella, Criado, Alejandro ORCID: 0000-0002-9732-513X, Istif, Akcan, Mancino, Donato, Dominguez, Antonio, Eckert, Hagen ORCID: 0000-0003-4771-1435, Vazquez, Ester, Da Ros, Tatiana, Nicolussi, Paola, Palermo, Vincenzo, Schumacher, Bjoern, Cuniberti, Gianaurelio, Mai, Yiyong, Clementi, Cecilia, Pasquali, Matteo, Feng, Xinliang, Kostarelos, Kostas, Yilmazer, Acelya, Bedognetti, Davide, Fadeel, Bengt, Prato, Maurizio, Bianco, Alberto and Delogu, Lucia Gemma ORCID: 0000-0002-2329-7260 (2020). Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design. J. Phys-Mater., 3 (3). BRISTOL: IOP PUBLISHING LTD. ISSN 2515-7639

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Abstract

Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gazzi, AriannaUNSPECIFIEDorcid.org/0000-0002-4142-485XUNSPECIFIED
Fusco, LauraUNSPECIFIEDorcid.org/0000-0003-1418-507XUNSPECIFIED
Orecchioni, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrari, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franzoni, GiuliaUNSPECIFIEDorcid.org/0000-0003-0987-3863UNSPECIFIED
Yan, J. StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieckher, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peng, GuotaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lucherelli, Matteo AndreaUNSPECIFIEDorcid.org/0000-0003-1055-3269UNSPECIFIED
Anna Vacchi, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Criado, AlejandroUNSPECIFIEDorcid.org/0000-0002-9732-513XUNSPECIFIED
Istif, AkcanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mancino, DonatoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominguez, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckert, HagenUNSPECIFIEDorcid.org/0000-0003-4771-1435UNSPECIFIED
Vazquez, EsterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Da Ros, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nicolussi, PaolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palermo, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuniberti, GianaurelioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mai, YiyongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clementi, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pasquali, MatteoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feng, XinliangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kostarelos, KostasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yilmazer, AcelyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedognetti, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fadeel, BengtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prato, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bianco, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delogu, Lucia GemmaUNSPECIFIEDorcid.org/0000-0002-2329-7260UNSPECIFIED
URN: urn:nbn:de:hbz:38-327488
DOI: 10.1088/2515-7639/ab9317
Journal or Publication Title: J. Phys-Mater.
Volume: 3
Number: 3
Date: 2020
Publisher: IOP PUBLISHING LTD
Place of Publication: BRISTOL
ISSN: 2515-7639
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ASBESTOS-LIKE PATHOGENICITY; PULMONARY TOXICITY; TRANSCRIPTIONAL REGULATION; CAENORHABDITIS-ELEGANS; LATERAL DIMENSION; IN-VITRO; NANOTUBES; OXIDE; CELLS; MICEMultiple languages
Materials Science, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32748

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