Universität zu Köln

Stockebrand, Malte, Hornig, Soenke, Neu, Axel ORCID: 0000-0001-7045-7194, Atzler, Dorothee ORCID: 0000-0002-6551-1544, Cordts, Kathrin, Boeger, Rainer H., Isbrandt, Dirk, Schwedhelm, Edzard and Choe, Chi-un (2015). Homoarginine supplementation improves blood glucose in diet-induced obese mice. Amino Acids, 47 (9). S. 1921 - 1930. WIEN: SPRINGER WIEN. ISSN 1438-2199

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Abstract

l-Homoarginine (hArg) is an endogenous amino acid which has emerged as a novel biomarker for stroke and cardiovascular disease. Low circulating hArg levels are associated with increased mortality and vascular events, whereas recent data have revealed positive correlations between circulating hArg and metabolic vascular risk factors like obesity or blood glucose levels. However, it is unclear whether hArg levels are causally linked to metabolic parameters. Therefore, the aim of our study was to investigate whether hArg directly influences body weight, blood glucose, glucose tolerance or insulin sensitivity. Here, we show that hArg supplementation (14 and 28 mg/mL orally per drinking water) ameliorates blood glucose levels in mice on high-fat diet (HFD) by a reduction of 7.3 +/- A 3.7 or 13.4 +/- A 3.8 %, respectively. Fasting insulin concentrations were slightly, yet significantly affected (63.8 +/- A 11.3 or 162.1 +/- A 39.5 % of control animals, respectively), whereas body weight and glucose tolerance were unaltered. The substantial augmentation of hArg plasma concentrations in supplemented animals (327.5 +/- A 40.4 or 627.5 +/- A 60.3 % of control animals, respectively) diminished profoundly after the animals became obese (129.9 +/- A 16.6 % in control animals after HFD vs. 140.1 +/- A 8.5 or 206.3 +/- A 13.6 %, respectively). This hArg-lowering effect may contribute to the discrepancy between the inverse correlation of plasma hArg levels with stroke and cardiovascular outcome, on the one hand, and the direct correlation with cardiovascular risk factors like obesity and blood glucose, on the other hand, that has been observed in human studies. Our results suggest that the glucose-lowering effects of hArg may reflect a compensatory mechanism of blood glucose reduction by hArg upregulation in obese individuals, without directly influencing body weight or glucose tolerance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stockebrand, Malte UNSPECIFIED UNSPECIFIED UNSPECIFIED Hornig, Soenke UNSPECIFIED UNSPECIFIED UNSPECIFIED Neu, Axel UNSPECIFIED orcid.org/0000-0001-7045-7194 UNSPECIFIED Atzler, Dorothee UNSPECIFIED orcid.org/0000-0002-6551-1544 UNSPECIFIED Cordts, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Boeger, Rainer H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbrandt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwedhelm, Edzard UNSPECIFIED UNSPECIFIED UNSPECIFIED Choe, Chi-un UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394595
DOI:	10.1007/s00726-015-2022-1
Journal or Publication Title:	Amino Acids
Volume:	47
Number:	9
Page Range:	S. 1921 - 1930
Date:	2015
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1438-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDUCED INSULIN-RELEASE; NITRIC-OXIDE SYNTHASE; CATIONIC AMINO-ACIDS; L-ARGININE; CARDIOVASCULAR RISK; ARGINASE I; BETA-CELL; AMIDINOTRANSFERASE; POPULATION; INHIBITORS Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39459