Universität zu Köln

Herbig, Elisa, Mücke, Doris ORCID: 0000-0002-6217-3121, Barbe, Michael T. ORCID: 0000-0003-1149-8054 and Thies, Tabea ORCID: 0000-0001-9149-3143 (2025). Executive dysfunctions impair and levodopa improves articulatory timing in Parkinson‘s disease. Frontiers in Human Neuroscience, 19. Frontier. ISSN 1662-5161

PDF fnhum-19-1580376.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (2MB)

Abstract

[Artikel-Nr. 1580376] This study investigates the effects of executive functions and levodopa on articulatory timing patterns in simple and complex syllable onsets (CV vs. CCV) in Parkinson’s disease (PD). Kinematic speech data (EMA) of 25 individuals with PD in medication-OFF as well as medication-ON condition and 25 healthy controls (HC) were recorded, and group differences were examined. Results showed preserved articulatory coordination that is skewed in time in the PD group as well as a positive effect of levodopa on these patterns. Cluster analysis revealed an age-dependent decline in executive functions across groups that correlated with the shift pattern of the second consonant in CCV sequences for the PD group. This indicates that executive dysfunctions could give rise to changes in articulatory timing patterns as the disease progresses but independently of general motor severity.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Herbig, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Mücke, Doris doris.muecke@uni-koeln.de https://orcid.org/0000-0002-6217-3121 UNSPECIFIED Barbe, Michael T. UNSPECIFIED https://orcid.org/0000-0003-1149-8054 UNSPECIFIED Thies, Tabea UNSPECIFIED https://orcid.org/0000-0001-9149-3143 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-788263
Identification Number:	10.3389/fnhum.2025.1580376
Journal or Publication Title:	Frontiers in Human Neuroscience
Volume:	19
Date:	2 July 2025
Publisher:	Frontier
ISSN:	1662-5161
Language:	English
Faculty:	Collaborative Research Centers Faculty of Arts and Humanities Faculty of Medicine
Divisions:	Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Arts and Humanities > Fächergruppe 1: Kunstgeschichte, Musikwissenschaft, Medienkultur und Theater, Linguistik, Digital Humanities > Institut für Linguistik (IfL) > Abteilung für Phonetik (PHO) Collaborative Research Centers > CRC 1252: Prominence in Language > TP A04
Subjects:	Language, Linguistics Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/78826