Universität zu Köln

Thierbach, Anne, Di Cristanziano, Veronica ORCID: 0000-0003-1604-8386, Eberhardt, Kirsten A., Pirkl, Martin ORCID: 0000-0002-6986-0813, Steger, Gertrud ORCID: 0000-0002-0581-8122, Heger, Eva ORCID: 0000-0001-7625-5139, Kaiser, Rolf ORCID: 0000-0002-2640-2548, Koch, Manuel ORCID: 0000-0002-2962-7814, Klein, Florian ORCID: 0000-0003-1376-1792, Rauschning, Dominic ORCID: 0000-0001-9284-8778 and Malin, Jakob J. ORCID: 0000-0002-2989-0436 (2025). High rate of RNAemia and impaired immunity in patients with immunodeficiency in the vaccination era. Journal of Clinical Virology, 177. pp. 1-5. Elsevier. ISSN 1386-6532

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Abstract

[Artikel-Nr. 105774] Background: Immunocompromised individuals, hemato-oncologic diseases or post-transplantation included, are, due to impaired immune response, at increased risk for severe and prolonged COVID-19. Observational Studies showed that SARS-CoV-2 RNAemia has been associated with poorer prognosis and higher disease severity. Objective: The aim of this study was to investigate the occurrence of RNAemia and its association with anti-SARS- CoV-2 antibodies in immunocompromised COVID-19 patients. Risk factors for RNAemia were included in the analysis. Study design: A retrospective study was conducted in 55 immunocompromised patients tested positive for SARS- CoV-2, who received treatment with monoclonal antibodies (mAb) between December 2021 and March 2022. Serological and virological tests were performed before mAb administration and clinical data were collected from electronic health records. Results: Out of 55 patients, 35 % showed SARS-CoV-2 RNAemia. RNAemia was present in the 2 reported fatal cases. It was associated with negative testing for anti-receptor binding domain (RBD) IgG, anti-S2 domain of spike protein (S2) IgG and a lower leukocyte count. No association was found between previous COVID-19 vaccinations and the risk for RNAemia in immunocompromised patients. Conclusion: The study underscores the importance of humoral response in controlling SARS-CoV-2 replication. RNAemia can serve as a potential biomarker for disease severity in immunocompromised individuals. Therefore, it should be considered in clinical settings for appropriate therapy decisions. Further research is needed to evaluate the pathophysiology and implications of RNAemia in immunodeficient patients with COVID-19.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Thierbach, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED https://orcid.org/0000-0003-1604-8386 UNSPECIFIED Eberhardt, Kirsten A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pirkl, Martin UNSPECIFIED https://orcid.org/0000-0002-6986-0813 UNSPECIFIED Steger, Gertrud UNSPECIFIED https://orcid.org/0000-0002-0581-8122 UNSPECIFIED Heger, Eva UNSPECIFIED https://orcid.org/0000-0001-7625-5139 UNSPECIFIED Kaiser, Rolf UNSPECIFIED https://orcid.org/0000-0002-2640-2548 UNSPECIFIED Koch, Manuel UNSPECIFIED https://orcid.org/0000-0002-2962-7814 UNSPECIFIED Klein, Florian UNSPECIFIED https://orcid.org/0000-0003-1376-1792 UNSPECIFIED Rauschning, Dominic UNSPECIFIED https://orcid.org/0000-0001-9284-8778 UNSPECIFIED Malin, Jakob J. UNSPECIFIED https://orcid.org/0000-0002-2989-0436 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794397
Identification Number:	10.1016/j.jcv.2025.105774
Journal or Publication Title:	Journal of Clinical Virology
Volume:	177
Page Range:	pp. 1-5
Number of Pages:	1
Date:	April 2025
Publisher:	Elsevier
ISSN:	1386-6532
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Anästhesiologie und Operative Intensivmedizin > Klinik für Anästhesiologie und Operative Intensivmedizin Faculty of Medicine > Virologie > Institut für Virologie Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79439