Universität zu Köln

Scharfenberg, Daniel ORCID: 0000-0003-2781-3143, Kalbe, Elke ORCID: 0000-0001-8603-2545, Balzer‐Geldsetzer, Monika, Berg, Daniela ORCID: 0000-0001-5796-5442, Hilker‐Roggendorf, Rüdiger, Kassubek, Jan ORCID: 0000-0002-7106-9270, Liepelt‐Scarfone, Inga ORCID: 0000-0002-0875-892X, Mollenhauer, Brit, Reetz, Kathrin ORCID: 0000-0002-9730-9228, Riedel, Oliver ORCID: 0000-0002-1721-502X, Roeske, Sandra ORCID: 0000-0002-8262-4356, Schulz, Jörg B. ORCID: 0000-0002-8903-0593, Storch, Alexander ORCID: 0000-0002-1133-9216, Trenkwalder, Claudia, Witt, Karsten, Wittchen, Hans‐Ulrich, Dodel, Richard ORCID: 0000-0003-2044-6299 and Ophey, Anja ORCID: 0000-0001-5858-7762 (2025). A network perspective on cognition in individuals with Parkinson's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17 (1). pp. 1-10. Wiley. ISSN 2352-8729

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Abstract

[Artikel-Nr. e70091] INTRODUCTION: In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson’s disease (PD) and conceptually replicate the findings in cognitively healthy individuals (CHIs). METHODS: We performed Exploratory Graph Analysis (EGA) for dimensionality analysis of cognitive test scores in N = 698 individuals with PD from the DEM- PARK/LANDSCAPE study. Redundancy was reduced based on Unique Variable Anal- ysis (UVA) before re-performing EGA. CHI data (N = 60,398) served as a conceptual replication base. RESULTS: EGA identified five dimensions. After removing redundancy identified by UVA, EGA identified a unidimensional structure of cognitive test scores. The findings were conceptually replicated in CHIs. DISCUSSION: The findings imply the need to re-evaluate the composition of cognitive test batteries to reduce redundancy and improve the validity of cognitive diagnostics. Cognition may be better described as a network of interrelated cognitive functions rather than a factorial structure of latent cognitive domains.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Scharfenberg, Daniel UNSPECIFIED https://orcid.org/0000-0003-2781-3143 UNSPECIFIED Kalbe, Elke UNSPECIFIED https://orcid.org/0000-0001-8603-2545 UNSPECIFIED Balzer‐Geldsetzer, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED https://orcid.org/0000-0001-5796-5442 UNSPECIFIED Hilker‐Roggendorf, Rüdiger UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED https://orcid.org/0000-0002-7106-9270 UNSPECIFIED Liepelt‐Scarfone, Inga UNSPECIFIED https://orcid.org/0000-0002-0875-892X UNSPECIFIED Mollenhauer, Brit UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED https://orcid.org/0000-0002-9730-9228 UNSPECIFIED Riedel, Oliver UNSPECIFIED https://orcid.org/0000-0002-1721-502X UNSPECIFIED Roeske, Sandra UNSPECIFIED https://orcid.org/0000-0002-8262-4356 UNSPECIFIED Schulz, Jörg B. UNSPECIFIED https://orcid.org/0000-0002-8903-0593 UNSPECIFIED Storch, Alexander UNSPECIFIED https://orcid.org/0000-0002-1133-9216 UNSPECIFIED Trenkwalder, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, Hans‐Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED https://orcid.org/0000-0003-2044-6299 UNSPECIFIED Ophey, Anja UNSPECIFIED https://orcid.org/0000-0001-5858-7762 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794433
Identification Number:	10.1002/dad2.70091
Journal or Publication Title:	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume:	17
Number:	1
Page Range:	pp. 1-10
Date:	24 January 2025
Publisher:	Wiley
ISSN:	2352-8729
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Psychiatrie und Psychotherapie > Klinik und Poliklinik für Psychiatrie und Psychotherapie
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79443