Universität zu Köln

Vishwakarma, Pratima ORCID: 0000-0003-3373-904X, Mestanoglu, Mert ORCID: 0000-0002-7984-5959, Welge‐Lüßen, Veronika, Schlereth, Simona ORCID: 0000-0002-7230-6434, Cursiefen, Claus ORCID: 0000-0002-1958-411X and Bachmann, Björn ORCID: 0000-0002-3974-7609 (2025). Anterior segment optical coherence tomography (AS‐OCT) assisted analysis of characteristics of graft dehiscence after Descemet membrane endothelial keratoplasty (DMEK) for failed penetrating keratoplasty. Acta Ophthalmologica, 103 (4). pp. 365-485. Wiley. ISSN 1755-375X

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Abstract

Purpose: To analyse anterior segment optical coherence tomography (AS- OCT) parameters of graft dehiscence after Descemet membrane endothelial kerato- plasty (DMEK) for graft failure post penetrating keratoplasty (PK). Methods: Retrospective evaluation of AS- OCT images of 142 dehiscences post- DMEK in 75 eyes. Dehiscences' size, depth, location, correlation with graft- host interface (GHI) override and step at GHI were assessed. Results: The majority of patients were male (58.7%) and mean age was 67 ± 13.6 years. Multiple dehiscences were observed in 49.3% eyes. Rebubbling was required once in 72% and multiple times in 24% eyes. Among 142 dehis- cences, crossing over GHI was noted in 53.5%. The median distance of periph- eral edge of dehiscences from GHI was 0.21 mm. Steps at GHI were noted in 41.5% where 22.5% dehiscences with step crossed the GHI. For dehiscences crossing versus not crossing GHI, no significant difference was noted in me- dian depth (p = 0.268) and size (p = 0.206). For dehiscences crossing over GHI with presence versus absence of step, median depth (p = 0.23) and size (p = 0.196) showed no significant difference. No significant difference was noted in dehis- cences' median depth (p = 0.16) and size (p = 0.926) among different step sizes. Incidence of dehiscence with or without steps (p = 0.8853) and graded as per size of steps, showed no significant difference. Conclusion: Size and depth of dehiscence were not influenced by their crossing over GHI or the presence and size of steps. Dehiscences typically occurred in close vicinity to GHI, suggesting that DMEK graft should be placed 0.25 mm centrally from the prior PK interface, independ. KEYWORDS: anterior segment optical coherence tomography, descemet membrane endothelial keratoplasty, graft dehiscence, graft failure, penetrating keratoplasty

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Vishwakarma, Pratima UNSPECIFIED https://orcid.org/0000-0003-3373-904X UNSPECIFIED Mestanoglu, Mert UNSPECIFIED https://orcid.org/0000-0002-7984-5959 UNSPECIFIED Welge‐Lüßen, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlereth, Simona UNSPECIFIED https://orcid.org/0000-0002-7230-6434 UNSPECIFIED Cursiefen, Claus UNSPECIFIED https://orcid.org/0000-0002-1958-411X UNSPECIFIED Bachmann, Björn UNSPECIFIED https://orcid.org/0000-0002-3974-7609 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794504
Identification Number:	10.1111/aos.17445
Journal or Publication Title:	Acta Ophthalmologica
Volume:	103
Number:	4
Page Range:	pp. 365-485
Date:	21 June 2025
Publisher:	Wiley
ISSN:	1755-375X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Augenheilkunde > Klinik und Poliklinik für Allgemeine Augenheilkunde Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79450