Universität zu Köln

Lohner, Valerie ORCID: 0000-0001-5589-9701, Perna, Laura ORCID: 0000-0002-7383-9806, Schöttker, Ben ORCID: 0000-0002-1217-4521, Perneczky, Robert ORCID: 0000-0003-1981-7435, Brenner, Hermann and Mons, Ute ORCID: 0000-0003-1764-6783 (2025). Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome. Experimental Gerontology, 200. pp. 1-7. Elsevier. ISSN 0531-5565

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Abstract

[Artikel-Nr. 112684] Background: In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS). Methods: We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype. Results: Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ40/Aβ42-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on ApoE ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes. Conclusions: In persons with CSS, NfL and the Aβ40/Aβ42-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by ApoE genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Lohner, Valerie UNSPECIFIED https://orcid.org/0000-0001-5589-9701 UNSPECIFIED Perna, Laura UNSPECIFIED https://orcid.org/0000-0002-7383-9806 UNSPECIFIED Schöttker, Ben UNSPECIFIED https://orcid.org/0000-0002-1217-4521 UNSPECIFIED Perneczky, Robert UNSPECIFIED https://orcid.org/0000-0003-1981-7435 UNSPECIFIED Brenner, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Mons, Ute UNSPECIFIED https://orcid.org/0000-0003-1764-6783 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794548
Identification Number:	10.1016/j.exger.2025.112684
Journal or Publication Title:	Experimental Gerontology
Volume:	200
Page Range:	pp. 1-7
Number of Pages:	1
Date:	February 2025
Publisher:	Elsevier
ISSN:	0531-5565
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79454