Universität zu Köln

Ophey, Anja ORCID: 0000-0001-5858-7762, Vinod, Vaishali ORCID: 0000-0002-2951-2208, Röttgen, Sinah ORCID: 0000-0002-7553-2111, Scharfenberg, Daniel ORCID: 0000-0003-2781-3143, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Sommerauer, Michael ORCID: 0000-0001-5723-9766, Kalbe, Elke ORCID: 0000-0001-8603-2545, Maetzler, Walter ORCID: 0000-0002-5945-4694 and Hansen, Clint ORCID: 0000-0003-4813-3868 (2025). Accelerometry-derived features of physical activity, sleep and circadian rhythm relate to non-motor symptoms in individuals with isolated REM sleep behavior disorder. Journal of Neurology, 272 (3). Springer Nature. ISSN 0340-5354

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Abstract

[Artikel-Nr. 201] Accelerometry enables passive, continuous, high-frequency monitoring under free-living conditions. For individuals with isolated REM sleep behavior disorder (iRBD), a potential prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies, accelerometry has been primarily applied to aid diagnosis and to assess phenoconversion risk. To extend this knowledge, we cross-sectionally combined clinical assessments focusing on non-motor symptoms with accelerometry-derived features of physical activity (PA), sleep, and circadian rhythm of N = 68 individuals with iRBD (age: 69.48 ± 6.01 years, self-reported RBD symptom duration: 9.46 ± 6.21 years, 85 % male). Accelerometry-assessed PA was associated with more stable circadian rhythms. Additionally, higher PA and more stable circadian rhythms were linked to a lower burden of overall non-motor symptoms, depressive symptoms, and fatigue with small to moderate effect sizes. Furthermore, including accelerometry-derived features improved the prediction of individual clinical scores, particularly for cognitive performance. Our findings contribute to the growing body of evidence highlighting the complex interplay between PA, sleep, circadian rhythm, and non-motor symptoms in α-synucleinopathies. Future research should focus on longitudinal studies to monitor changes in clinical outcomes and digital biomarkers over time to enhance our understanding of symptom progression and corresponding lifestyle changes in prodromal and manifest α-synucleinopathies.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Ophey, Anja UNSPECIFIED https://orcid.org/0000-0001-5858-7762 UNSPECIFIED Vinod, Vaishali UNSPECIFIED https://orcid.org/0000-0002-2951-2208 UNSPECIFIED Röttgen, Sinah UNSPECIFIED https://orcid.org/0000-0002-7553-2111 UNSPECIFIED Scharfenberg, Daniel UNSPECIFIED https://orcid.org/0000-0003-2781-3143 UNSPECIFIED Fink, Gereon R. UNSPECIFIED https://orcid.org/0000-0002-8230-1856 UNSPECIFIED Sommerauer, Michael UNSPECIFIED https://orcid.org/0000-0001-5723-9766 UNSPECIFIED Kalbe, Elke UNSPECIFIED https://orcid.org/0000-0001-8603-2545 UNSPECIFIED Maetzler, Walter UNSPECIFIED https://orcid.org/0000-0002-5945-4694 UNSPECIFIED Hansen, Clint UNSPECIFIED https://orcid.org/0000-0003-4813-3868 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-797924
Identification Number:	10.1007/s00415-025-12931-6
Journal or Publication Title:	Journal of Neurology
Volume:	272
Number:	3
Date:	11 March 2025
Publisher:	Springer Nature
ISSN:	0340-5354
Language:	English
Faculty:	Central Institutions / Interdisciplinary Research Centers Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Medizinische Psychologie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79792