Universität zu Köln

Zhao, Yue ORCID: 0000-0002-6790-3402 (2025). Targeting oncogenic acetyltransferase NAT10 to overcome anti-PD-1 resistance in nasopharyngeal carcinoma. Journal for ImmunoTherapy of Cancer, 13 (10). pp. 1-3. BMJ Group. ISSN 2051-1426

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Abstract

[Artikel-Nr. e012254] Targeted resistance to immune checkpoint therapy remains a clinical challenge, and a recent study reported by Xie et al provides novel insights into how RNA acetylation, particularly N4-acetylcytidine (ac 4 C), plays a pivotal role in shaping the tumor immune microenvironment in nasopharyngeal carcinoma (NPC). Through elucidation of the NAT10/DDX5/high mobility group box 1 axis, the authors demonstrate that enhanced ac 4 C modification suppresses CD4 + and CD8 + T-cell functionality, thereby facilitating tumor immune evasion and the resistance to anti-programmed cell death protein-1 therapy. This commentary evaluates the significance of these findings within the broader context of epitranscriptomic regulation research in oncology, identifies critical knowledge gaps regarding the equilibrium between immunosuppression and immune activation, and examines the therapeutic potential of NAT10 inhibition as a potential combinatorial approach in cancer immunotherapy. This work advances our understanding of how post-transcriptional RNA modifications influence tumor-immune interactions, establishing a conceptual framework for future investigations aimed at optimizing immunotherapeutic approaches in NPC and potentially other malignancies.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Zhao, Yue UNSPECIFIED https://orcid.org/0000-0002-6790-3402 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-798475
Identification Number:	10.1136/jitc-2025-012254
Journal or Publication Title:	Journal for ImmunoTherapy of Cancer
Volume:	13
Number:	10
Page Range:	pp. 1-3
Number of Pages:	1
Date:	20 October 2025
Publisher:	BMJ Group
ISSN:	2051-1426
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79847