Universität zu Köln

Oda, Hirotsugu ORCID: 0000-0002-1411-5381, Annibaldi, Alessandro ORCID: 0000-0002-0346-4340, Kastner, Daniel L. and Aksentijevich, Ivona (2025). Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases. Annual Review of Immunology, 43 (1). pp. 313-342. Annual Reviews. ISSN 0732-0582

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Abstract

Metazoans have evolved innate antimicrobial defenses that promote cellular survival and proliferation. Countering the inevitable molecular mechanisms by which microbes sabotage these pathways, multicellular organisms rely on an alternative, perhaps more ancient, strategy that is the immune equivalent of suicide bombing: Infection triggers cell death programs that summon localized or even systemic inflammation. The study of human genetics has now unveiled a level of complexity that refutes the naive view that cell death is merely a blunt instrument or an evolutionary afterthought. To the contrary, findings from patients with rare diseases teach us that cell death–induced inflammation is a sophisticated, tightly choreographed process. We herein review the emerging body of evidence describing a group of illnesses—inborn errors of cell death, which define many of the molecular building blocks and regulatory elements controlling cell death–induced inflammation in humans—and provide a possible road map to countering this process across the spectrum of rare and common illnesses.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Oda, Hirotsugu UNSPECIFIED https://orcid.org/0000-0002-1411-5381 UNSPECIFIED Annibaldi, Alessandro UNSPECIFIED https://orcid.org/0000-0002-0346-4340 UNSPECIFIED Kastner, Daniel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aksentijevich, Ivona UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-799536
Identification Number:	10.1146/annurev-immunol-090222-105848
Journal or Publication Title:	Annual Review of Immunology
Volume:	43
Number:	1
Page Range:	pp. 313-342
Number of Pages:	30
Date:	25 April 2025
Publisher:	Annual Reviews
ISSN:	0732-0582
Language:	English
Faculty:	Central Institutions / Interdisciplinary Research Centers Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79953