Hollenbeck, Jana Caroline and Ising, Christina 
ORCID: 0000-0002-7267-3488
(2025).
Wie Tau die Reaktionen von Mikroglia in Tauopathien beeinflusst.
BIOspektrum, 31 (5).
pp. 494-496.
Springer Nature.
ISSN 0947-0867
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Abstract
Neuroinflammation and tau aggregation are hallmarks of tauopathies. Microglial NLRP3 inflammasome activation, initiated by tau, is a key mediator in these diseases, resulting in the release of pro-inflammatory IL-1β and neuronal damage. However, microglia can also present with other disease-associated states such as cellular senescence, which can be driven by tau. Senescent microglia are characterized by a sustained cytokine release, exacerbating disease progression.
| Item Type: | Article |
| Creators: | Creators Email ORCID ORCID Put Code Hollenbeck, Jana Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED |
| URN: | urn:nbn:de:hbz:38-801114 |
| Identification Number: | 10.1007/s12268-025-2526-5 |
| Journal or Publication Title: | BIOspektrum |
| Volume: | 31 |
| Number: | 5 |
| Page Range: | pp. 494-496 |
| Number of Pages: | 3 |
| Date: | 4 September 2025 |
| Publisher: | Springer Nature |
| ISSN: | 0947-0867 |
| Language: | German |
| Faculty: | Faculty of Medicine |
| Divisions: | CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases |
| Subjects: | Medical sciences Medicine |
| ['eprint_fieldname_oa_funders' not defined]: | Publikationsfonds UzK |
| Refereed: | Yes |
| URI: | http://kups.ub.uni-koeln.de/id/eprint/80111 |
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