Universität zu Köln

Sonntag, Nadine ORCID: 0009-0003-6310-5221, Eichner, Markus, Judge, Michael, Kocher, Martin ORCID: 0000-0002-5674-9227, Ruess, Daniel ORCID: 0000-0003-1811-5132, Ruge, Maximilian I ORCID: 0000-0003-0466-6646 and Hunsche, Stefan ORCID: 0000-0002-0059-1758 (2025). Comparative evaluation of normal tissue objective functions in robotic radiosurgery planning for solitary brain tumors. Journal of Applied Clinical Medical Physics, 26 (11). pp. 1-9. Wiley. ISSN 1526-9914

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Abstract

[Artikel-Nr.: e70318] Background: The normal tissue objective (NTO) is an inverse planning approach in radiosurgery, also available for the CyberKnife system. By employing a model function, it aims to achieve precise control over the global dose fall‐off in healthy tissue. As a novel technique, NTO can serve as an alternative to the established method, which utilizes layered contours around the target to shape dose gradients and enhance conformity, referred to as Auto‐shells in CyberKnife systems. Purpose: This study compares the dose distribution achieved with NTO and Auto‐shells to evaluate their respective advantages in CyberKnife treatment planning. Methods: A total of 45 patients with brain tumors—including 15 vestibular schwannomas, 15 meningiomas, and 15 metastases, all of whom had previously been treated using an Auto‐shells‐generated plan, were analyzed. For each case, an alternative NTO‐based plan was generated and compared with its Auto‐shells counterpart. Key treatment parameters—including nodes, beams, total monitor units (MU), treatment time, new conformity index (nCI), gradient index (GI), and dose exposure volumes to healthy brain tissue (V12Gy and V5Gy)—were evaluated. Results: Both methods resulted in comparable plans across many indices. Significant differences were particularly in terms of healthy brain tissue dose exposure. With the NTO method, V12Gy and V5Gy were reduced by up to 14%, and in the case of meningiomas and metastases, the GI was reduced by up to 7%. The conformity, described by the nCI, was within 2%. No significant difference was observed in MU. Conclusion: NTO optimization presents a viable option to the Auto‐shells method for CyberKnife treatment of brain tumors. By reducing healthy brain tissue exposure without increasing monitor units, it enhances dose‐sparing efficiency. However, maintaining optimal conformity remains an important issue, highlighting the trade‐offs between precision and tissue preservation.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Sonntag, Nadine UNSPECIFIED https://orcid.org/0009-0003-6310-5221 UNSPECIFIED Eichner, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Judge, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocher, Martin UNSPECIFIED https://orcid.org/0000-0002-5674-9227 UNSPECIFIED Ruess, Daniel UNSPECIFIED https://orcid.org/0000-0003-1811-5132 UNSPECIFIED Ruge, Maximilian I UNSPECIFIED https://orcid.org/0000-0003-0466-6646 UNSPECIFIED Hunsche, Stefan UNSPECIFIED https://orcid.org/0000-0002-0059-1758 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-801649
Identification Number:	10.1002/acm2.70318
Journal or Publication Title:	Journal of Applied Clinical Medical Physics
Volume:	26
Number:	11
Page Range:	pp. 1-9
Number of Pages:	9
Date:	24 November 2025
Publisher:	Wiley
ISSN:	1526-9914
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie Faculty of Medicine > Strahlentherapie > Klinik und Poliklinik für Radioonkologie, Cyberknife- und Strahlentherapie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Cyberknife ; non-isocentric irradiation ; optimization ; stereotactic radiosurgery English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80164