Universität zu Köln

Kuehne, Benjamin ORCID: 0000-0003-3131-8794, Hellmich, Martin ORCID: 0000-0001-5174-928X, Heine, Eva, Kribs, Angela ORCID: 0000-0002-0477-5474, Mehler, Katrin ORCID: 0000-0002-3052-2147 and Oberthuer, André ORCID: 0000-0002-6856-9872 (2025). Neurodevelopmental Outcomes of Very Low Birth Weight Infants Following Extrauterine Placental Perfusion: A Follow‐Up Study. Acta Paediatrica, 114 (9). pp. 2246-2252. Wiley. ISSN 0803-5253

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Abstract

Aim: Extrauterine placental perfusion (EPP) may be a feasible cord clamping strategy in very low birth weight (VLBW) infants to support neonatal transition. However, the impact of EPP on neurodevelopment remains unclear. The study aimed to compare the effects of EPP with time‐based delayed cord clamping (DCC) on neurodevelopmental outcomes. Methods: This follow‐up study of the randomised controlled EXPLAIN (Extrauterine Placental Transfusion in Resuscitation of Very Low Birth Weight Infants) trial ( ClinicalTrials.gov Identifier: NCT03916159) was conducted at a tertiary perinatal centre from 2021 to 2023. Antenatally randomised VLBW infants received either EPP or DCC (> 30 s). Neurodevelopment was assessed at 24 months of corrected age using the Bayley Scales of Infant and Toddler Development, Third Edition. Data analysis was intention‐to‐treat. Results: Of 59 infants enrolled, 54 (92%) participated in the follow‐up (27 EPP, 27 DCC). Median age at assessment was 24.3 months (range 23.5–25.0); 28 (52%) were male. Infant characteristics and short‐term outcomes were similar between groups. No relevant differences were observed in median cognitive, motor or language scores or in rates of cerebral palsy, hearing, or visual impairment. Conclusion: The neurodevelopment of the VLBW infants who received EPP and DCC was comparable, suggesting that EPP may be a viable alternative.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kuehne, Benjamin UNSPECIFIED https://orcid.org/0000-0003-3131-8794 UNSPECIFIED Hellmich, Martin UNSPECIFIED https://orcid.org/0000-0001-5174-928X UNSPECIFIED Heine, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED https://orcid.org/0000-0002-0477-5474 UNSPECIFIED Mehler, Katrin UNSPECIFIED https://orcid.org/0000-0002-3052-2147 UNSPECIFIED Oberthuer, André UNSPECIFIED https://orcid.org/0000-0002-6856-9872 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-801767
Identification Number:	10.1111/apa.70101
Journal or Publication Title:	Acta Paediatrica
Volume:	114
Number:	9
Page Range:	pp. 2246-2252
Number of Pages:	7
Date:	18 September 2025
Publisher:	Wiley
ISSN:	0803-5253
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin Faculty of Medicine > Medizinische Statistik und Bioinformatik > Institut für Medizinische Statistik und Bioinformatik � IMSB
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language extrauterine placental perfusion ; neurodevelopmental outcome ; physiological based cord clamping ; very low birth weight infants English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80176