Taramasso, Maurizio, Benfari, Giovanni ORCID: 0000-0002-5660-6162, van der Bijl, Pieter, Alessandrini, Hannes, Attinger-Toller, Adrian, Biasco, Luigi, Lurz, Philipp, Braun, Daniel, Brochet, Eric, Connelly, Kim A., de Bruijn, Sabine, Denti, Paolo ORCID: 0000-0002-3075-0203, Deuschl, Florian, Estevez-Loureiro, Rodrigo ORCID: 0000-0001-5841-5514, Fam, Neil, Frerker, Christian, Gavazzoni, Mara, Hausleiter, Joerg, Ho, Edwin, Juliard, Jean-Michel, Kaple, Ryan, Besler, Christian, Kodali, Susheel, Kreidel, Felix, Kuck, Karl-Heinz, Latib, Azeem ORCID: 0000-0001-9035-343X, Lauten, Alexander, Monivas, Vanessa, Mehr, Michael, Muntane-Carol, Guillem, Nazif, Tamin, Nickening, Georg, Pedrazzini, Giovanni, Philippon, Francois, Pozzoli, Alberto, Praz, Fabien, Puri, Rishi, Rodes-Cabau, Josep, Schaefer, Ulrich, Schofer, Joachim, Sievert, Horst, Tang, Gilbert H. L., Thiele, Holger, Topilsky, Yan, Rommel, Karl-Philipp, Delgado, Victoria, Vahanian, Alec, Von Bardeleben, Ralph Stephan, Webb, John G., Weber, Marcel, Windecker, Stephan, Winkel, Mirjam, Zuber, Michel, Leon, Martin B., Hahn, Rebecca T., Bax, Jeroen J., Enriquez-Sarano, Maurice and Maisano, Francesco (2019). Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation. J. Am. Coll. Cardiol., 74 (24). S. 2998 - 3009. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-3597

Full text not available from this repository.

Abstract

BACKGROUND Tricuspid regurgitation is associated with increased rates of heart failure (HF) and mortality. Transcatheter tricuspid valve interventions (TTVI) are promising, but the clinical benefit is unknown. OBJECTIVES The purpose of this study was to investigate the potential benefit of TTVI over medical therapy in a propensity score matched population. METHODS The TriValve (Transcatheter Tricuspid Valve Therapies) registry collected 472 patients from 22 European and North American centers who underwent TTVI from 2016 to 2018. A control cohort formed by 2 large retrospective registries enrolling medically managed patients with >= moderate tricuspid regurgitation in Europe and North America (n = 1,179) were propensity score 1:1 matched (distance +/- 0.2 SD) using age, EuroSCORE II, and systolic pulmonary artery pressure. Survival was tested with Cox regression analysis. Primary endpoint was 1-year mortality or HF rehospitalization or the composite. RESULTS After matching, 268 adequately matched pairs of patients were identified. Compared with control subjects, TTVI patients had lower 1-year mortality (23 +/- 3% vs. 36 +/- 3%; p = 0.001), rehospitalization (26 +/- 3% vs. 47 +/- 3%; p < 0.0001), and composite endpoint (32 +/- 4% vs. 49 +/- 3%; p = 0.0003). TTVI was associated with greater survival and freedom from HF rehospitalization (hazard ratio [HR]: 0.60; 95% confidence interval [CI]: 0.46 to 0.79; p = 0.003 unadjusted), which remained significant after adjusting for sex, New York Heart Association functional class, right ventricular dysfunction, and atrial fibrillation (HR: 0.39; 95% CI: 0.26 to 0.59; p < 0.0001) and after further adjustment for mitral regurgitation and pacemaker/defibrillator (HR: 0.35; 95% CI: 0.23 to 0.54; p < 0.0001). CONCLUSIONS In this propensity-matched case-control study, TTVI is associated with greater survival and reduced HF rehospitalization compared with medical therapy alone. Randomized trials should be performed to confirm these results. (C) 2019 by the American College of Cardiology Foundation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Taramasso, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benfari, GiovanniUNSPECIFIEDorcid.org/0000-0002-5660-6162UNSPECIFIED
van der Bijl, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alessandrini, HannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attinger-Toller, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biasco, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lurz, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brochet, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Connelly, Kim A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Bruijn, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denti, PaoloUNSPECIFIEDorcid.org/0000-0002-3075-0203UNSPECIFIED
Deuschl, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Estevez-Loureiro, RodrigoUNSPECIFIEDorcid.org/0000-0001-5841-5514UNSPECIFIED
Fam, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frerker, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gavazzoni, MaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hausleiter, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ho, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juliard, Jean-MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaple, RyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besler, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kodali, SusheelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreidel, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuck, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Latib, AzeemUNSPECIFIEDorcid.org/0000-0001-9035-343XUNSPECIFIED
Lauten, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monivas, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehr, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muntane-Carol, GuillemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nazif, TaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickening, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pedrazzini, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Philippon, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pozzoli, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Praz, FabienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puri, RishiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodes-Cabau, JosepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schofer, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sievert, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tang, Gilbert H. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Topilsky, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rommel, Karl-PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delgado, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vahanian, AlecUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Von Bardeleben, Ralph StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Webb, John G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Windecker, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkel, MirjamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuber, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leon, Martin B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahn, Rebecca T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enriquez-Sarano, MauriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maisano, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-124261
DOI: 10.1016/j.jacc.2019.09.028
Journal or Publication Title: J. Am. Coll. Cardiol.
Volume: 74
Number: 24
Page Range: S. 2998 - 3009
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1558-3597
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NATIVE VALVULAR REGURGITATION; VALVE REPAIR; EUROPEAN ASSOCIATION; MANAGEMENT; OUTCOMES; SOCIETY; RECOMMENDATIONS; CONGESTION; DISEASE; SURGERYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12426

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item