Universität zu Köln

Lucio, Marianna, Willkommen, Desiree, Schroeter, Michael, Sigaroudi, Ali ORCID: 0000-0002-3176-4631, Schmitt-Kopplin, Philippe ORCID: 0000-0003-0824-2664 and Michalke, Bernhard (2019). Integrative Metabolomic and Metallomic Analysis in a Case-Control Cohort With Parkinson's Disease. Front. Aging Neurosci., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Parkinson's disease (PD) is a neurodegenerative disease with a complex etiology. Several factors are known to contribute to the disease onset and its progression. However, the complete underlying mechanisms are still escaping our understanding. To evaluate possible correlations between metabolites and metallomic data, in this research, we combined a control study measured using two different platforms. For the different data sources, we applied a Block Sparse Partial Least Square Discriminant Analysis (Block-sPLS-DA) model that allows for proving their relation, which in turn uncovers alternative influencing factors that remain hidden otherwise. We found two groups of variables that trace a strong relationship between metallomic and metabolomic parameters for disease development. The results confirmed that the redox active metals iron (Fe) and copper (Cu) together with fatty acids are the major influencing factors for the PD. Additionally, the metabolic waste product p-cresol sulfate and the trace element nickel (Ni) showed up as potentially important factors in PD. In summary, the data integration of different types of measurements emphasized the results of both stand-alone measurements providing a new comprehensive set of information and interactions, on PD disease, between different variables sources.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lucio, Marianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Willkommen, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sigaroudi, Ali UNSPECIFIED orcid.org/0000-0002-3176-4631 UNSPECIFIED Schmitt-Kopplin, Philippe UNSPECIFIED orcid.org/0000-0003-0824-2664 UNSPECIFIED Michalke, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124678
DOI:	10.3389/fnagi.2019.00331
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	11
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBROSPINAL-FLUID; MANGANESE EXPOSURE; NEURODEGENERATION; PREVALENCE; COMPONENT; METALS; COPPER; SERUM; IRON Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12467