Jenks, Jeffrey D., Rawlings, Stephen A., Garcia-Vidal, Carol, Koehler, Philipp ORCID: 0000-0002-7386-7495, Mercier, Toine ORCID: 0000-0002-1517-6426, Prattes, Juergen ORCID: 0000-0001-5751-9311, Lass-Floerl, Cornelia, Teresa Martin-Gomez, M., Buchheidt, Dieter ORCID: 0000-0002-4425-6134, Pagano, Livio, Gangneux, Jean-Pierre ORCID: 0000-0002-4974-5607, van de Veerdonk, Frank L., Netea, Mihai G., Carvalho, Agostinho ORCID: 0000-0001-8935-8030 and Hoenigl, Martin ORCID: 0000-0002-1653-2824 (2019). Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection. J. Fungi, 5 (4). BASEL: MDPI. ISSN 2309-608X

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Abstract

Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jenks, Jeffrey D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rawlings, Stephen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Vidal, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
Mercier, ToineUNSPECIFIEDorcid.org/0000-0002-1517-6426UNSPECIFIED
Prattes, JuergenUNSPECIFIEDorcid.org/0000-0001-5751-9311UNSPECIFIED
Lass-Floerl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teresa Martin-Gomez, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchheidt, DieterUNSPECIFIEDorcid.org/0000-0002-4425-6134UNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gangneux, Jean-PierreUNSPECIFIEDorcid.org/0000-0002-4974-5607UNSPECIFIED
van de Veerdonk, Frank L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Netea, Mihai G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carvalho, AgostinhoUNSPECIFIEDorcid.org/0000-0001-8935-8030UNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
URN: urn:nbn:de:hbz:38-125388
DOI: 10.3390/jof5040116
Journal or Publication Title: J. Fungi
Volume: 5
Number: 4
Date: 2019
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2309-608X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BRONCHOALVEOLAR LAVAGE FLUID; LATERAL-FLOW DEVICE; ASPERGILLUS-FUMIGATUS; PULMONARY ASPERGILLOSIS; TRANSPLANT RECIPIENTS; INTERLEUKIN (IL)-6; GALACTOMANNAN; SERUM; POLYMORPHISMS; PERFORMANCEMultiple languages
Microbiology; MycologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12538

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