Universität zu Köln

Grau, Marijke, Nader, Elie ORCID: 0000-0002-6054-2456, Jerke, Max, Schenk, Alexander, Renoux, Celine, Dietz, Thomas, Collins, Bianca, Bizjak, Daniel Alexander, Joly, Philippe, Bloch, Wilhelm, Prokop, Aram and Connes, Philippe ORCID: 0000-0002-9232-0268 (2019). Impact of A Six Week Training Program on Ventilatory Efficiency, Red Blood Cell Rheological Parameters and Red Blood Cell Nitric Oxide Signaling in Young Sickle Cell Anemia Patients: A Pilot Study. J. Clin. Med., 8 (12). BASEL: MDPI. ISSN 2077-0383

Full text not available from this repository.

Abstract

Patients with sickle cell anemia (SCA) show impaired ventilatory efficiency, altered blood rheology, high levels of oxidative/nitrosative stress and enhanced hemolysis with large amounts of circulating free hemoglobin, which reduces nitric oxide (NO) bioavailability. The aim of the study was to investigate whether physical exercise could improve these physiological and biological markers described to contribute to SCA pathophysiology. Twelve SCA patients participated in a controlled six weeks training program with moderate volume (two sessions per week with 15-30 min duration per session) and intensity (70% of the first ventilatory threshold). Parameters were compared before (T0) and after (T1) training. Daily activities were examined by a questionnaire at T0 and one year after the end of T1. Results revealed improved ventilatory efficiency, reduced nitrosative stress, reduced plasma free hemoglobin concentration, increased plasma nitrite levels and altered rheology at T1 while no effect was observed for exercise performance parameters or hematological profile. Red blood cell (RBC) NO parameters indicate increased NO bioavailability which did not affect RBC deformability. Participants increased their daily life activity level. The data from this pilot study concludes that even low intensity activities are feasible and could be beneficial for the health of SCA patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grau, Marijke UNSPECIFIED UNSPECIFIED UNSPECIFIED Nader, Elie UNSPECIFIED orcid.org/0000-0002-6054-2456 UNSPECIFIED Jerke, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Renoux, Celine UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietz, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Collins, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Bizjak, Daniel Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Joly, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED Connes, Philippe UNSPECIFIED orcid.org/0000-0002-9232-0268 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125473
DOI:	10.3390/jcm8122155
Journal or Publication Title:	J. Clin. Med.
Volume:	8
Number:	12
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MODERATE ENDURANCE EXERCISE; ANAEROBIC THRESHOLD; OXIDATIVE STRESS; PLASMA NITRITE; AGGREGATE STRENGTH; SYNTHASE ACTIVITY; CHILDREN; HEMOGLOBIN; DISEASE; DEFORMABILITY Multiple languages Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12547