Universität zu Köln

Kambeitz-Ilankovic, Lana, Betz, Linda T., Dominke, Clara, Haas, Shalaila S., Subramaniam, Karuna, Fisher, Melisa, Vinogradov, Sophia, Koutsouleris, Nikolaos and Kambeitz, Joseph (2019). Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes. Neurosci. Biobehav. Rev., 107. S. 828 - 846. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7528

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Abstract

Cognitive remediation (CR) is nowadays mainly administered in a computerized fashion, yet frequently supplemented by human guidance. The effects of CR on cognitive, functional and clinical outcomes are consistently reported, yet the response is heterogeneous. In order to resolve this heterogeneity, we employed a multi-outcome meta-analytic approach, examined effects of CR on each outcome category separately and estimated directed effects between three outcome categories. We extracted treatment effects from 67 studies that trained patients with schizophrenia (total n = 4067) using either 1) computerized CR modality alone or 2) in combination with supplementary human guidance (SHG). All three outcome domains were significantly improved by CR with small to moderate effect sizes when assessing outcomes across all studies. The comparison between CR administered with SHG revealed largest effects on the cognitive subdomains of working and verbal memory. Structural equation modeling in the single-study data suggests that cognitive gains trigger restoration of psychosocial functioning which in turn facilitates Improvement in clinical symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kambeitz-Ilankovic, Lana UNSPECIFIED UNSPECIFIED UNSPECIFIED Betz, Linda T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dominke, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Shalaila S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Subramaniam, Karuna UNSPECIFIED UNSPECIFIED UNSPECIFIED Fisher, Melisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Vinogradov, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125897
DOI:	10.1016/j.neubiorev.2019.09.031
Journal or Publication Title:	Neurosci. Biobehav. Rev.
Volume:	107
Page Range:	S. 828 - 846
Date:	2019
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7528
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CONTROLLED-TRIAL; CLINICAL HIGH-RISK; NEGATIVE SYMPTOMS; 1ST-EPISODE SCHIZOPHRENIA; NEUROCOGNITION; IDENTIFICATION; INDIVIDUALS; MULTICENTER; PSYCHOSIS; EFFICACY Multiple languages Behavioral Sciences; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12589