Universität zu Köln

Meyer, Melissa M., Schmidt, Alexander, Benrath, Justus, Konstandin, Simon, Pilz, Lothar R., Harrington, Michael G., Budjan, Johannes, Meyer, Mathias, Schad, Lothar R., Schoenberg, Stefan O. and Haneder, Stefan (2019). Cerebral sodium (Na-23) magnetic resonance imaging in patients with migraine - a case-control study. Eur. Radiol., 29 (12). S. 7055 - 7063. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objective Evaluation of MRI-derived cerebral Na-23 concentrations in patients with migraine in comparison with healthy controls. Materials and methods In this case-control study, 24 female migraine patients (mean age, 3411 years) were enrolled after evaluation of standardized questionnaires. Half (n=12) of the cohort suffered from migraine, the other half was impaired by both migraine and tension-type headaches (TTH). The combined patient cohort was matched to 12 healthy female controls (mean age, 3411 years). All participants underwent a cerebral Na-23-magnetic resonance imaging examination at 3.0 T, which included a T1w MP-RAGE sequence and a 3D density-adapted, radial gradient echo sequence for Na-23 imaging. Circular regions of interests were placed in predetermined anatomic regions: cerebrospinal fluid (CSF), gray and white matter, brain stem, and cerebellum. External Na-23 reference phantoms were used to calculate the total Na-23 tissue concentrations. Pearson's correlation, Kendall Tau, and Wilcoxon rank sum test were used for statistical analysis. Results Na-23 concentrations of all patients in the CSF were significantly higher than in healthy controls (p<0.001). The CSF of both the migraine and mixed migraine/TTH group showed significantly increased sodium concentrations compared to the control group (p=0.007 and p<0.001). Within the patient cohort, a positive correlation between pain level and TSC in the CSF (r=0.62) could be observed. Conclusion MRI-derived cerebral Na-23 concentrations in the CSF of migraine patients were found to be statistically significantly higher than in healthy controls.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Melissa M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Benrath, Justus UNSPECIFIED UNSPECIFIED UNSPECIFIED Konstandin, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilz, Lothar R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harrington, Michael G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Budjan, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schad, Lothar R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenberg, Stefan O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125968
DOI:	10.1007/s00330-019-06299-1
Journal or Publication Title:	Eur. Radiol.
Volume:	29
Number:	12
Page Range:	S. 7055 - 7063
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TENSION-TYPE HEADACHE; HUMAN BRAIN; MRI Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12596