Universität zu Köln

Koliamitra, Christina, Javelle, Florian ORCID: 0000-0003-4240-2588, Joisten, Niklas, Shimabukuro-Vornhagen, Alexander, Bloch, Wilhelm, Schenk, Alexander and Zimmer, Philipp (2019). Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term? - A Theoretical Frame Work Supported by Pilot Data. J. Sport. Sci. Med., 18 (4). S. 669 - 674. BURSA: JOURNAL SPORTS SCIENCE & MEDICINE. ISSN 1303-2968

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Abstract

Regular physical activity and exercise interventions are suspected to have anti-inflammatory effects depending on exercise modality, thereby potentially reducing the risk and progress of several chronic diseases. Alterations in the kynurenine pathway may represent a link between inflammatory responses following acute exercise and chronic anti-inflammatory properties, such as increased levels of regulatory T-cells (T-reg). Here, we hypothesize that acute exercise activates the kynurenine pathway and physical fitness is associated with proportions of circulating anti-inflammatory T-reg in older healthy women. Nineteen older healthy female participants (55 years (SD: +/- 5.6)) completed a cardiopulmonary incremental exercise test (CPET) with spirometry on a bicycle ergometer until exhaustion with maximum oxygen uptake (VO(2)max) as outcome. Blood samples were taken before (T0) and one minute after (T1) the CPET. Levels of tryptophan, serotonin and kynurenine were determined by enzyme-linked immunosorbent assays. Flow cytometry was used to identify proportions of T-cell subsets. Both, kynurenine (p = 0.003, d = 0.40) and the kynurenine/tryptophan ratio (p = 0.034, d = 0.48) increased significantly after acute exercise. Moreover, participants' VO(2)max was strongly correlated with T-reg levels (p < 0.001, r = 0.689). This is the first study indicating a kynurenine pathway activation following acute exercise in older healthy women. The observed correlation between T-reg levels and VO(2)max emphasizes a potential link between short-term upregulated kynurenine levels and longer-term anti-inflammatory properties of exercise. Future research is needed to clarify to what extend acute exercise-induced activations of the kynurenine pathway contribute to T-reg differentiation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koliamitra, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Javelle, Florian UNSPECIFIED orcid.org/0000-0003-4240-2588 UNSPECIFIED Joisten, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126367
Journal or Publication Title:	J. Sport. Sci. Med.
Volume:	18
Number:	4
Page Range:	S. 669 - 674
Date:	2019
Publisher:	JOURNAL SPORTS SCIENCE & MEDICINE
Place of Publication:	BURSA
ISSN:	1303-2968
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORTISOL; DISEASE; CANCER Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12636