Universität zu Köln

Bennani-Baiti, Barbara, Krug, Barbara, Giese, Daniel ORCID: 0000-0002-3925-4441, Hellmich, Martin, Bartsch, Sophie, Helbich, Thomas H. and Baltzer, Pascal A. T. (2019). Evaluation of 3.0-T MRI Brain Signal after Exposure to Gadoterate Meglumine in Women with High Breast Cancer Risk and Screening Breast MRI. Radiology, 293 (3). S. 523 - 531. OAK BROOK: RADIOLOGICAL SOC NORTH AMERICA. ISSN 0033-8419

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Abstract

Background: Otherwise healthy women at high risk for breast cancer undergo annual contrast agent-enhanced breast MRI screening examinations, resulting in high cumulative doses of gadolinium-based contrast agents (GBCAs). Whereas the majority of studies showed no T1 signal ratio increase in deep brain nuclei after more than six doses of macrocyclic GBCA, this has not been explored in a healthy study population. Purpose: To assess whether women who are administered large cumulative doses of macrocyclic GBCA with breast MRI at high-risk breast cancer screening exhibit T1 alterations in deep brain nuclei. Materials and Methods: In this prospective study from November 2017 to March 2018, healthy women who were either exposed (because of high-risk breast cancer screening) or unexposed to only gadoterate meglumine underwent 3.0-T brain MRI with a dedicated head coil, including T1 mapping and magnetization-prepared rapid gradient-echo sequences. T1 times and T1 signal intensities were measured in the dentate nucleus (DN), globus pallidus (GP), crus anterior of capsula interna (CA), and pons. Ratios of DN to pons and GP to CA were calculated, and univariable Pearson correlation coefficients were calculated. Multivariable analysis included partial regression analysis. Results: This study evaluated 25 women (mean age, 51 years +/- 11 [standard deviation]) who were exposed to a mean GBCA dose of 129 mL (median 112 mL; range, 70-302 mL) and 16 women (mean age, 37 years +/- 10) who were never exposed to any GBCA. Infratentorially, no correlation between cumulative GBCA dose and T1 times or signal intensity ratios was detected (P = .66 and .55, respectively). In partial correlation analysis by considering age as a confounder, there was a moderate negative correlation between GP-to-CA ratio and GBCA dose (r = 20.40; P = .01) but not for GP T1 times (r = 0.19; P = .24). Conclusion: After administration of relatively large cumulative doses of gadoterate dimeglumine, healthy women at high risk for breast cancer who underwent annual contrast-enhanced breast MRI screening did not exhibit T1 signal increase in deep brain nucleiat 3.0-T MRI. (C) RSNA, 2019

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bennani-Baiti, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED orcid.org/0000-0002-3925-4441 UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartsch, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Helbich, Thomas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltzer, Pascal A. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126421
DOI:	10.1148/radiol.2019190847
Journal or Publication Title:	Radiology
Volume:	293
Number:	3
Page Range:	S. 523 - 531
Date:	2019
Publisher:	RADIOLOGICAL SOC NORTH AMERICA
Place of Publication:	OAK BROOK
ISSN:	0033-8419
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNENHANCED T1-WEIGHTED BRAIN; DENTATE NUCLEUS; GLOBUS-PALLIDUS; MAGNETIC-RESONANCE; CONTRAST AGENTS; GADOLINIUM DEPOSITION; MULTIPLE ADMINISTRATIONS; IMAGES; GADOBUTROL; INTENSITY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12642