Universität zu Köln

Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., Staffas, A., da Silva, M. Burgos, Devlin, S. M., Markey, K. A., Bajic, D., Pinedo, R., Tsakmaklis, A., Littmann, E. R., Pastore, A., Taur, Y., Monette, S., Arcila, M. E., Pickard, A. J., Maloy, M., Wright, R. J., Amoretti, L. A., Fontana, E., Pham, D., Jamal, M. A., Weber, D., Sung, A. D., Hashimoto, D., Scheid, C., Xavier, J. B., Messina, J. A., Romero, K., Lew, M., Bush, A., Bohannon, L., Hayasaka, K., Hasegawa, Y., Vehreschild, M. J. G. T., Cross, J. R., Ponce, D. M., Perales, M. A., Giralt, S. A., Jenq, R. R., Teshima, T., Holler, E., Chao, N. J., Pamer, E. G., Peled, J. U. and van den Brink, M. R. M. (2019). Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science, 366 (6469). S. 1143 - 1191. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that Enterococcus also expands in the mouse gastrointestinal tract after allo-HCT and exacerbates disease severity in gnotobiotic models. Enterococcus growth is dependent on the disaccharide lactose, and dietary lactose depletion attenuates Enterococcus outgrowth and reduces the severity of GVHD in mice. Allo-HCT patients carrying lactose-nonabsorber genotypes showed compromised clearance of postantibiotic Enterococcus domination. We report lactose as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stein-Thoeringer, C. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nichols, K. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lazrak, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Docampo, M. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Slingerland, A. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Slingerland, J. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clurman, A. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Armijo, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomes, A. L. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shono, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Staffas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED da Silva, M. Burgos UNSPECIFIED UNSPECIFIED UNSPECIFIED Devlin, S. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Markey, K. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bajic, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinedo, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsakmaklis, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Littmann, E. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pastore, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Taur, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Monette, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arcila, M. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pickard, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maloy, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wright, R. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amoretti, L. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fontana, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pham, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jamal, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sung, A. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hashimoto, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Xavier, J. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Messina, J. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Romero, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lew, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bush, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bohannon, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayasaka, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasegawa, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, M. J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cross, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponce, D. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Perales, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giralt, S. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jenq, R. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teshima, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holler, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chao, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pamer, E. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peled, J. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Brink, M. R. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126813
DOI:	10.1126/science.aax3760
Journal or Publication Title:	Science
Volume:	366
Number:	6469
Page Range:	S. 1143 - 1191
Date:	2019
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VANCOMYCIN-RESISTANT ENTEROCOCCUS; CELL; MICROBIOME; BACTEREMIA; RISK; COLONIZATION; CHEMOTHERAPY; ANTIBIOTICS; COMMENSALS; DOMINATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12681