Barbe, Michael T., Tonder, Lisa, Krack, Paul ORCID: 0000-0002-3508-7295, Debu, Bettina, Schupbach, Michael, Paschen, Steffen, Dembek, Till A., Kuehn, Andrea A., Fraix, Valerie, Brefel-Courbon, Christine, Wojtecki, Lars, Maltete, David, Damier, Phillippe, Sixel-Doering, Friederike, Weiss, Daniel, Pinsker, Marcus, Witjas, Tatiana, Thobois, Stephane, Schade-Brittinger, Carmen, Rau, Joern, Houeto, Jean-Luc, Hartmann, Andreas, Timmermann, Lars, Schnitzler, Alfons, Stoker, Valerie, Vidailhet, Marie, Deuschl, Guenther, Knudsen, K., Volkmann, J., Falk, D., Mehdorn, M., Haelbig, T. D., Hesekamp, H., Navarro, S. M., Meier, N., Agid, Y., Seigneuret, E., Kistner, A., Chaynes, P., Ory-Magne, F., Bataille, B., Raoul, S., Regis, J. -M., Mertens, P., Helwig, D., Oertel, W. H., Maarouf, M., Fink, G. R., Kupsch, A., Gruber, D., Schneider, G. -H., Vesper, J., Gharabaghi, A., Krueger, R. and Amtage, F. (2020). Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor Complications. Mov. Disord., 35 (1). S. 82 - 91. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background Effects of DBS on freezing of gait and other axial signs in PD patients are unclear. Objective Secondary analysis to assess whether DBS affects these symptoms within a large randomized controlled trial comparing DBS of the STN combined with best medical treatment and best medical treatment alone in patients with early motor complications (EARLYSTIM-trial). Methods One hundred twenty-four patients were randomized in the stimulation group and 127 patients in the best medical treatment group. Presence of freezing of gait was assessed in the worst condition based on item-14 of the UPDRS-II at baseline and follow-up. The posture, instability, and gait-difficulty subscore of the UPDRS-III, and a gait test including quantification of freezing of gait and number of steps, were performed in both medication-off and medication-on conditions. Results Fifty-two percent in both groups had freezing of gait at baseline based on UPDRS-II. This proportion decreased in the stimulation group to 34%, but did not change in the best medical treatment group at 24 months (P = 0.018). The steps needed to complete the gait test decreased in the stimulation group and was superior to the best medical treatment group (P = 0.016). The axial signs improved in the stimulation group compared to the best medical treatment group (P < 0.01) in both medication-off and medication-on conditions. Conclusions Within the first 2 years of DBS, freezing of gait and other axial signs improved in the medication-off condition compared to best medical treatment in these patients. (c) 2019 International Parkinson and Movement Disorder Society

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Barbe, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tonder, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krack, PaulUNSPECIFIEDorcid.org/0000-0002-3508-7295UNSPECIFIED
Debu, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schupbach, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paschen, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dembek, Till A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, Andrea A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fraix, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brefel-Courbon, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wojtecki, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maltete, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damier, PhillippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sixel-Doering, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinsker, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witjas, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thobois, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schade-Brittinger, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rau, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houeto, Jean-LucUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoker, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidailhet, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuentherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knudsen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falk, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehdorn, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haelbig, T. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hesekamp, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navarro, S. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meier, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agid, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seigneuret, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kistner, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaynes, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ory-Magne, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bataille, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raoul, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regis, J. -M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mertens, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helwig, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oertel, W. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maarouf, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, G. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupsch, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruber, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, G. -H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesper, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gharabaghi, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amtage, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-127267
DOI: 10.1002/mds.27892
Journal or Publication Title: Mov. Disord.
Volume: 35
Number: 1
Page Range: S. 82 - 91
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBTHALAMIC NUCLEUS STIMULATION; MEDICAL THERAPY; FOLLOW-UP; NEUROSTIMULATION; LEVODOPA; MULTICENTER; TRIALMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12726

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