Universität zu Köln

Moradi, Sharif ORCID: 0000-0002-2935-983X, Mahdizadeh, Hamid, Saric, Tomo, Kim, Johnny, Harati, Javad, Shahsavarani, Hosein, Greber, Boris and Moore, Joseph B. (2019). Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations. Stem Cell Res. Ther., 10 (1). LONDON: BMC. ISSN 1757-6512

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Abstract

Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (induced or reprogrammed) in culture from somatic cells through ectopic co-expression of defined pluripotency factors. Since they can be generated from any healthy person or patient, iPSCs are considered as a valuable resource for regenerative medicine to replace diseased or damaged tissues. In addition, reprogramming technology has provided a powerful tool to study mechanisms of cell fate decisions and to model human diseases, thereby substantially potentiating the possibility to (i) discover new drugs in screening formats and (ii) treat life-threatening diseases through cell therapy-based strategies. However, various legal and ethical barriers arise when aiming to exploit the full potential of iPSCs to minimize abuse or unauthorized utilization. In this review, we discuss bioethical, legal, and societal concerns associated with research and therapy using iPSCs. Furthermore, we present key questions and suggestions for stem cell scientists, legal authorities, and social activists investigating and working in this field.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moradi, Sharif UNSPECIFIED orcid.org/0000-0002-2935-983X UNSPECIFIED Mahdizadeh, Hamid UNSPECIFIED UNSPECIFIED UNSPECIFIED Saric, Tomo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Johnny UNSPECIFIED UNSPECIFIED UNSPECIFIED Harati, Javad UNSPECIFIED UNSPECIFIED UNSPECIFIED Shahsavarani, Hosein UNSPECIFIED UNSPECIFIED UNSPECIFIED Greber, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Moore, Joseph B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-127316
DOI:	10.1186/s13287-019-1455-y
Journal or Publication Title:	Stem Cell Res. Ther.
Volume:	10
Number:	1
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1757-6512
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFORMED-CONSENT; SOMATIC-CELLS; CLINICAL TRANSLATION; NAIVE PLURIPOTENCY; GENERATION; MOUSE; TUMORIGENICITY; INDUCTION; CLONING; MICE Multiple languages Cell & Tissue Engineering; Cell Biology; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12731