Universität zu Köln

Volz, Lukas J., Hamada, Masashi, Michely, Jochen, Pool, Eva-Maria ORCID: 0000-0001-8007-9588, Nettekoven, Charlotte, Rothwell, John C. and Hermann, Christian Grefkes . Modulation of I-wave generating pathways by theta-burst stimulation: a model of plasticity induction. J. Physiol.-London. HOBOKEN: WILEY. ISSN 1469-7793

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Abstract

Plasticity-induction following theta burst transcranial stimulation (TBS) varies considerably across subjects, and the underlying neurophysiological mechanisms remain poorly understood, representing a challenge for scientific and clinical applications. In human motor cortex (M1), recruitment of indirect waves (I-waves) can be probed by the excess latency of motor-evoked potentials elicited by transcranial magnetic stimulation with an anterior-posterior (AP) orientation over the latency of motor-evoked potentials evoked by direct activation of corticospinal axons using lateromedial (LM) stimulation, referred to as the 'AP-LM latency' difference. Importantly, AP-LM latency has been shown to predict individual responses to TBS across subjects. We, therefore, hypothesized that the plastic changes in corticospinal excitability induced by TBS are the result, at least in part, of changes in excitability of these same I-wave generating pathways. In 20 healthy subjects, we investigated whether intermittent TBS (iTBS) modulates I-wave recruitment as reflected by changes in the AP-LM latency. As expected, we found that AP-LM latencies before iTBS were associated with iTBS-induced excitability changes. A novel finding was that iTBS reduced AP-LM latency, and that this reduction significantly correlated with changes in cortical excitability observed following iTBS: subjects with larger reductions in AP-LM latencies featured larger increases in cortical excitability following iTBS. Our findings suggest that plasticity-induction by iTBS may derive from the modulation of I-wave generating pathways projecting onto M1, accounting for the predictive potential of I-wave recruitment. The excitability of I-wave generating pathways may serve a critical role in modulating motor cortical excitability and hence represent a promising target for novel repetitive transcranial magnetic stimulation protocols.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Volz, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamada, Masashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Michely, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pool, Eva-Maria UNSPECIFIED orcid.org/0000-0001-8007-9588 UNSPECIFIED Nettekoven, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothwell, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Christian Grefkes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-127804
DOI:	10.1113/JP278636
Journal or Publication Title:	J. Physiol.-London
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-7793
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; NETWORK CONNECTIVITY; INTERINDIVIDUAL VARIABILITY; CORTICAL EXCITABILITY; BRAIN-STIMULATION; SURFACE EMG; UPPER-LIMB; RESPONSES; AMPLITUDE Multiple languages Neurosciences; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12780