Universität zu Köln

Chon, Seung-Hun ORCID: 0000-0002-8923-6428, Bartella, Isabel and Buerger, Martin (2019). Endoscopic treatment options for adenocarcinoma of the esophagogastric junction. Onkologe, 25 (12). S. 1073 - 1080. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

Background The incidence of adenocarcinoma of the esophagogastric junction has increased in recent years. While a multimodal treatment concept is established for advanced carcinomas, the treatment of early stage carcinoma is still not clearly defined. Objective Presentation and overview of the endoscopic treatment options according to current data and knowledge. Material and methods A selective literature search was conducted in PubMed regarding endoscopic treatment of adenocarcinoma of the esophagogastric junction. Results and discussion Patients with a low risk of nodal metastasis are suitable for interventional endoscopic treatment. The indications apply particularly to carcinomas (T1a) limited to the mucosa and can in exceptional cases also apply to carcinomas with submucosal infiltration (T1b). Endoscopic treatment of these tumors should be performed in a two-step approach consisting of resection and an ablative procedure. The former is performed by endoscopic mucosal resection or endoscopic submucosal dissection. Subsequently, if residual Barrett epithelium is still present, radiofrequency ablation or argon plasma coagulation is recommended to minimize the likelihood of neoplastic recurrence. When endoscopic treatment is conducted at a large center with experienced endoscopists an oncological outcome equivalent to operative care can be achieved with a relevant complication rate <3%. The complications include bleeding, iatrogenic perforations or strictures. After successful endoscopic resection a close follow-up care must be performed. If a recurrence occurs endoscopic treatment can be repeated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chon, Seung-Hun UNSPECIFIED orcid.org/0000-0002-8923-6428 UNSPECIFIED Bartella, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-127995
DOI:	10.1007/s00761-019-00673-w
Journal or Publication Title:	Onkologe
Volume:	25
Number:	12
Page Range:	S. 1073 - 1080
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BARRETTS-ESOPHAGUS; RADIOFREQUENCY ABLATION; SUBMUCOSAL DISSECTION; MUCOSAL RESECTION; CANCER; INFILTRATION; MANAGEMENT; CARCINOMA; EFFICACY; THERAPY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12799