Universität zu Köln

Tribius, S., Wurdemann, N., Laban, S., Hoffmann, T. K., Sharma, S. J. and Klussmann, J. P. (2019). Update on HPV-associated head and neck cancer-highlights from the 2019 ASCO Annual Meeting. HNO, 67 (12). S. 912 - 918. NEW YORK: SPRINGER. ISSN 1433-0458

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Abstract

At this year's Annual Meeting of the American Society for Clinical Oncology (ASCO), the keyword search HPV-associated head and neck cancer resulted in 920 hits-74% of the hits on human papillomavirus (HPV). This underlines the relevance of the topic. The spectrum ranged from validation and separation of the prognostic groups of patients with HPV-associated oropharyngeal carcinoma (OPSCC) according to TNM 8, to the characterization of new tumor markers and tumor mutational burden for possible de-escalation strategies to avoid toxicity of standard multimodal treatments. It has been shown that the separation of p16-positive OPSCC into Union for International Cancer Control (UICC) stages I and II with the current TNM 8 classification without further markers is not sufficiently successful to justify de-escalation strategies. Following publication of the results of the De-ESCALaTE- and RTOG-1016 trials in 2018, which confirm the current standard of care for p16-positive OPSCC, no further phase III studies on de-escalation were presented. In a presented prospective phase II study (NCT02281955), the radiotherapy dose was reduced to cumulative 60 Gy, whereby the simultaneous chemotherapy regimen with cisplatin 30 mg/m(2) weekly is not standard of care and could be administered as an alternative to cisplatin cetuximab. Some work dealt with the oral and intestinal microbiota as prognostic markers or their treatment-related changes, particularly under immunotherapy. Modification seems to have a positive impact on the success of therapy. However, robust data are still lacking for the various modified treatments for HPV-associated OPSCC, which are needed before their implementation in daily practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tribius, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wurdemann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laban, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, T. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128078
DOI:	10.1007/s00106-019-00766-3
Journal or Publication Title:	HNO
Volume:	67
Number:	12
Page Range:	S. 912 - 918
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0458
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-PAPILLOMAVIRUS; 8TH EDITION; OROPHARYNGEAL CANCER; SURVIVAL; RISK Multiple languages Otorhinolaryngology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12807