Universität zu Köln

van Rijssen, Thomas J., van Dijka, Elon H. C., Yzer, Suzanne, Ohno-Matsui, Kyoko, Keunen, Jan E. E., Schlingemann, Reinier O., Sivaprasad, Sobha, Querques, Giuseppe, Downes, Susan M., Fauser, Sascha, Hoyng, Carel B., Piccolino, Felice Cardillo, Chhablani, Jay K., Lai, Timothy Y. Y., Lotery, Andrew J., Larsen, Michael, Holz, Frank G., Freund, K. Bailey ORCID: 0000-0002-7888-9773, Yannuzzi, Lawrence A. and Boon, Camiel J. F. (2019). Central serous chorioretinopathy: Towards an evidence-based treatment guideline. Prog. Retin. Eye Res., 73. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-1635

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Abstract

Central serous chorioretinopathy (CSC) is a common cause of central vision loss, primarily affecting men 20-60 years of age. To date, no consensus has been reached regarding the classification of CSC, and a wide variety of interventions have been proposed, reflecting the controversy associated with treating this disease. The recent publication of appropriately powered randomised controlled trials such as the PLACE trial, as well as large retrospective, non-randomised treatment studies regarding the treatment of CSC suggest the feasibility of a more evidence-based approach when considering treatment options. The aim of this review is to provide a comprehensive overview of the current rationale and evidence with respect to the variety of interventions available for treating CSC, including pharmacology, laser treatment, and photodynamic therapy. In addition, we describe the complexity of CSC, the challenges associated with treating CSC, and currently ongoing studies. Many treatment strategies such as photodynamic therapy using verteporfin, oral mineralocorticoid antagonists, and micropulse laser treatment have been reported as being effective. Currently, however, the available evidence suggests that half-dose (or half-fluence) photodynamic therapy should be the treatment of choice in chronic CSC, whereas observation may be the preferred approach in acute CSC. Nevertheless, exceptions can be considered based upon patient-specific characteristics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Rijssen, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijka, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yzer, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohno-Matsui, Kyoko UNSPECIFIED UNSPECIFIED UNSPECIFIED Keunen, Jan E. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlingemann, Reinier O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sivaprasad, Sobha UNSPECIFIED UNSPECIFIED UNSPECIFIED Querques, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Downes, Susan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piccolino, Felice Cardillo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chhablani, Jay K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lai, Timothy Y. Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lotery, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Larsen, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Holz, Frank G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, K. Bailey UNSPECIFIED orcid.org/0000-0002-7888-9773 UNSPECIFIED Yannuzzi, Lawrence A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128743
DOI:	10.1016/j.preteyeres.2019.07.003
Journal or Publication Title:	Prog. Retin. Eye Res.
Volume:	73
Date:	2019
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-1635
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOSE PHOTODYNAMIC THERAPY; INDOCYANINE GREEN ANGIOGRAPHY; TERM-FOLLOW-UP; POLYPOIDAL CHOROIDAL VASCULOPATHY; OPTICAL COHERENCE TOMOGRAPHY; SUBTHRESHOLD MICROPULSE LASER; MINERALOCORTICOID-RECEPTOR ANTAGONISTS; RETINAL-PIGMENT EPITHELIOPATHY; RANDOMIZED CLINICAL-TRIALS; COMPLEMENT FACTOR-H Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12874