Universität zu Köln

Sprenger, Hans-Georg and Langer, Thomas (2019). The Good and the Bad of Mitochondrial Breakups. Trends Cell Biol., 29 (11). S. 888 - 901. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3088

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Abstract

Mitochondrial morphology is a crucial determinant of mitochondrial and cellular function. Opposing fusion and fission events shape the tubular mitochondrial reticulum and ensure mitochondrial transport within cells. Cellular stress and pathophysiological conditions can lead to fragmentation of the mitochondrial network, which facilitates mitophagy and is associated with cell death. However, mitochondrial shape changes are also intertwined with the cellular metabolism, and metabolic switches can induce but also result from alterations in mitochondrial morphology. Here, we discuss recent advances in the field of mitochondrial dynamics, demonstrating cell- and tissue-specific effects of mitochondrial fragmentation on cellular metabolism, cell survival, and mitochondrial quality control.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sprenger, Hans-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-129522
DOI:	10.1016/j.tcb.2019.08.003
Journal or Publication Title:	Trends Cell Biol.
Volume:	29
Number:	11
Page Range:	S. 888 - 901
Date:	2019
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3088
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MITOFUSIN 2; ENDOPLASMIC-RETICULUM; SKELETAL-MUSCLE; LIFE-SPAN; DYNAMICS; FISSION; OPA1; FUSION; MFN2; CRISTAE Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12952