Universität zu Köln

Zirk, Matthias, Buller, Johannes, Zoeller, Joachim E., Heneweer, Carola, Kuebler, Norbert and Lentzen, Max-Philipp (2019). Volumetric analysis of MRONJ lesions by semiautomatic segmentation of CBCT images. Oral Maxillofac. Surg.-Heidelb., 23 (4). S. 465 - 473. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1865-1569

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Abstract

Purpose The purpose of this study was to evaluate potential differences in volumes of areas of osteolysis caused by medication-related osteonecrosis of the jaw (MRONJ) between the upper and lower jaw. We aim to analyze the clinical relevance of volumetric measurement of osteolytic lesions for surgical planning of MRONJ patients. Methods Sixty-seven patients who were clinically and histopathologically diagnosed with MRONJ were retrospectively included in this study. Cone beam computed tomography (CBCT) images were evaluated according to localization, affected anatomical structures, and volumetric measurement of osteolytic lesions caused by MRONJ in appliance of CBCT datasets by using ITK-SNAP. Results The most frequently affected localization is the mandible, whereas female patients show significantly more often lesions of the maxilla. The cortical bone was predominantly affected. Furthermore, the affection of teeth, sinus floor, inferior alveolar nerve canal, or even a pathological fracture of the mandible are infrequently existing. The volumetric measurements revealed a statistically significant greater absolute osteolysis volume in males. Conclusions Image analysis and volumetric measurements of osteolytic lesions of MRONJ patients is a helpful tool to further understand the clinical appearance and identify compromised anatomic landmarks. Volumetric analysis aids in pre-surgical planning and visualizes the individual extent of the disease for each patient.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zirk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Buller, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneweer, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuebler, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Lentzen, Max-Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130094
DOI:	10.1007/s10006-019-00805-x
Journal or Publication Title:	Oral Maxillofac. Surg.-Heidelb.
Volume:	23
Number:	4
Page Range:	S. 465 - 473
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1865-1569
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEDICATION-RELATED OSTEONECROSIS; BISPHOSPHONATE-RELATED OSTEONECROSIS; BEAM COMPUTED-TOMOGRAPHY; RISK-FACTORS; JAW; MANAGEMENT; DIAGNOSIS; PREVALENCE; OUTCOMES; THERAPY Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13009