Universität zu Köln

Berron, David ORCID: 0000-0003-1558-1883, Cardenas-Blanco, Arturo, Bittner, Daniel, Metzger, Coraline D., Spottke, Annika, Heneka, Michael T., Fliessbach, Klaus, Schneider, Anja ORCID: 0000-0001-9540-8700, Teipel, Stefan J., Wagner, Michael ORCID: 0000-0003-2589-6440, Speck, Oliver ORCID: 0000-0002-6019-5597, Jessen, Frank and Duezel, Emrah (2019). Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. J. Neurosci., 39 (44). S. 8788 - 8798. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

Mnemonic discrimination, the ability to distinguish similar events in memory, relies on subregions in the human medial temporal lobes (MTLs). Tau pathology is frequently found within the MTL of older adults and therefore likely to affect mnemonic discrimination, even in healthy older individuals. The MTL subregions that are known to be affected early by tau pathology, the perirhinal-transentorhinal region (area 35) and the anterior-lateral entorhinal cortex (alEC), have recently been implicated in the mnemonic discrimination of objects rather than scenes. Here we used an object-scene mnemonic discrimination task in combination with fMRI recordings and analyzed the relationship between subregional MTL activity, memory performance, and levels of total and phosphorylated tau as well as A beta 42/40 ratio in CSF. We show that activity in alEC was associated with mnemonic discrimination of similar objects but not scenes in male and female cognitively unimpaired older adults. Importantly, CSF tau levels were associated with increased fMRI activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. This suggests that dysfunction of the alEC-hippocampus object mnemonic discrimination network might be a marker for tau-related cognitive decline.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Berron, David UNSPECIFIED orcid.org/0000-0003-1558-1883 UNSPECIFIED Cardenas-Blanco, Arturo UNSPECIFIED UNSPECIFIED UNSPECIFIED Bittner, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, Coraline D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Teipel, Stefan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Speck, Oliver UNSPECIFIED orcid.org/0000-0002-6019-5597 UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130133
DOI:	10.1523/JNEUROSCI.1279-19.2019
Journal or Publication Title:	J. Neurosci.
Volume:	39
Number:	44
Page Range:	S. 8788 - 8798
Date:	2019
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTEROLATERAL ENTORHINAL CORTEX; AGE-RELATED DEFICITS; PATTERN SEPARATION; COGNITIVE IMPAIRMENT; SIMILARITY TASK; MEMORY; DECLINE; FMRI; NETWORK; SYSTEMS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13013