Universität zu Köln

Ren, Si-Qiang, Li, Zhizhong, Lin, Susan, Bergami, Matteo ORCID: 0000-0001-5525-5025 and Shi, Song-Hai (2019). Precise Long-Range Microcircuit-to-Microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian Brain. Neuron, 104 (2). S. 385 - 405. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

The frontal area of the cerebral cortex provides long-range inputs to sensory areas to modulate neuronal activity and information processing. These long-range circuits are crucial for accurate sensory perception and complex behavioral control; however, little is known about their precise circuit organization. Here we specifically identified the presynaptic input neurons to individual excitatory neuron clones as a unit that constitutes functional microcircuits in the mouse sensory cortex. Interestingly, the long-range input neurons in the frontal but not contralateral sensory area are spatially organized into discrete vertical clusters and preferentially form synapses with each other over nearby non-input neurons. Moreover, the assembly of distant presynaptic microcircuits in the frontal area depends on the selective synaptic communication of excitatory neuron clones in the sensory area that provide inputs to the frontal area. These findings suggest that highly precise long-range reciprocal microcircuit-to-microcircuit communication mediates frontal-sensory area interactions in the mammalian cortex.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ren, Si-Qiang UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Zhizhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Susan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED orcid.org/0000-0001-5525-5025 UNSPECIFIED Shi, Song-Hai UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130507
DOI:	10.1016/j.neuron.2019.06.028
Journal or Publication Title:	Neuron
Volume:	104
Number:	2
Page Range:	S. 385 - 405
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREFRONTAL CORTEX; NEURAL-NETWORKS; DOWN INFLUENCES; MOTOR CORTEX; NEURONS; CIRCUIT; CELL; INTEGRATION; SINGLE; ORGANIZATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13050