Universität zu Köln

Kreitz, Kiana, Ernst, Angela ORCID: 0000-0003-2375-1889, Schmidt, Rene, Simon, Thorsten, Fischer, Matthias, Volland, Ruth, Hero, Barbara and Berthold, Frank ORCID: 0000-0002-7613-1723 (2019). A new risk score for patients after first recurrence of stage 4 neuroblastoma aged >= 18 months at first diagnosis. Cancer Med., 8 (17). S. 7236 - 7244. HOBOKEN: WILEY. ISSN 2045-7634

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Abstract

Background The prognosis of patients with recurrences from stage 4 neuroblastoma is not uniformly dismal. The evaluation of new therapies therefore needs to consider the individual risks of the treated patients. This study aims to define clinically useful risk criteria. Patients and Methods Inclusion criteria were: first recurrence of neuroblastoma stage 4 aged >= 18 months and enrollment in first line trials between 1997 and 2016. Patients were randomized into a training set (N = 310) and an independent validation set (N = 159). The primary endpoint was secondary event-free survival. The individual treatment elements the patients received during initial and recurrent disease were analyzed as binary and time-dependent variables. A five-step multiple time-dependent Cox regression analysis was performed on the training set to identify prognostic variables adjusted for the individual frontline treatment. The selected variables resulted in a prognostic index (PI) and were used to build a risk score system. The score was validated with the validation set. Results Of the 469 patients, 372 were treated with curative intent and 97 with palliative intent. The PI included the variables number of recurrence organs (hazard ratio [HR] = 2.27), time to recurrence (HR = 2.03), liver metastasis at diagnosis (HR = 1.77), first recurrence at site of the primary tumor (HR = 1.55), and age (HR = 1.29). Three risk groups were built and confirmed in the validation set. The scoring system was likewise useful for the curatively or palliatively treated subgroups. Conclusion A new risk score system for patients with first recurrence of stage 4 neuroblastoma aged >= 18 months at diagnosis is proposed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreitz, Kiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Angela UNSPECIFIED orcid.org/0000-0003-2375-1889 UNSPECIFIED Schmidt, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Volland, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Frank UNSPECIFIED orcid.org/0000-0002-7613-1723 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130630
DOI:	10.1002/cam4.2562
Journal or Publication Title:	Cancer Med.
Volume:	8
Number:	17
Page Range:	S. 7236 - 7244
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2045-7634
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REFRACTORY NEUROBLASTOMA; SURVIVAL; PROGRESSION; CHILDREN; RELAPSE Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13063