Universität zu Köln

Mellinghoff, Sibylle C., Otto, Christina and Cornely, Oliver A. (2019). Surgical site infections: current management and role of new antibiotics. Curr. Opin. Infect. Dis., 32 (5). S. 517 - 523. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-6527

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Abstract

Purpose of review Management of SSI comprises prevention, extensive diagnosis, and appropriate treatment as well as follow-up. All these are interrelated matters. This review gives a brief update on the latest developments in the field, specifically on new antibiotics that may find a place in this complex field. Recent findings Avibactam and dalbavancin are novel antiinfectives. Although randomized controlled trials in SSI are lacking to date, preliminary data show that new drugs may be alternatives to existing treatment. Currently, they should be used only on the ground of susceptibility testing, and if standard drugs are inappropriate. Correct diagnosis of SSI depends on the type of procedure performed. However, early detection is of great importance for proper management across all surgical interventions. The management of SSI includes consistent antibiotic therapy, wound drainage, and rigorous wound debridement as appropriate. Specific wound management thereafter depends on the location and nature of infection. If available, culture findings guide changes in antibiotic therapy. Avibactam and dalbavancin are novel antiinfectives that should be used on ground of susceptibility testing in the absence of appropriate alternatives. Follow-up is particularly important in patients with prosthesis in place. The most promising approach of postdischarge surveillance is a matter of ongoing debate.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131652
DOI:	10.1097/QCO.0000000000000589
Journal or Publication Title:	Curr. Opin. Infect. Dis.
Volume:	32
Number:	5
Page Range:	S. 517 - 523
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-6527
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAPHYLOCOCCUS-AUREUS BACTEREMIA; INGUINAL-HERNIA REPAIR; POSTDISCHARGE SURVEILLANCE; PROPHYLAXIS; SURGERY; IMPACT; RISK; DALBAVANCIN; PREVENTION; NETWORK Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13165