Universität zu Köln

Fuerstenau, Moritz, De Silva, Nisha, Eichhorst, Barbara and Hallek, Michael J. (2019). Minimal Residual Disease Assessment in CLL: Ready for Use in Clinical Routine? Hemasphere, 3 (5). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2572-9241

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Abstract

The introduction of chemoimmunotherapy and more recently the implementation of novel agents into first-line and relapse treatment have substantially improved treatment outcomes in patients with chronic lymphocytic leukaemia (CLL). With longer progression-free survival and more frequently observed deep remissions there is an emerging need for sensitive methods quantitating residual disease after therapy. Over the last decade, assessment of minimal residual disease (MRD) has increasingly been implemented in CLL trials. The predictive value of MRD status on survival outcomes has repeatedly been proven in the context of chemoimmunotherapy and cellular therapies. Recent data suggests a similar correlation for Bcl-2 inhibitor-based therapy. While the relevance of MRD assessment as a surrogate endpoint in clinical trials is largely undisputed, its role in routine clinical practice has not yet been well defined. This review outlines current methods of MRD detection in CLL and summarizes MRD data from relevant trials. The significance of MRD testing in clinical studies and in routine patient care is assessed and new MRD-guided treatment strategies are discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fuerstenau, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED De Silva, Nisha UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichhorst, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131739
DOI:	10.1097/HS9.0000000000000287
Journal or Publication Title:	Hemasphere
Volume:	3
Number:	5
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2572-9241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; TIME QUANTITATIVE PCR; FLOW-CYTOMETRY; INDEPENDENT PREDICTOR; PROGRESSION-FREE; FREE SURVIVAL; OPEN-LABEL; CELL TRANSPLANTATION; 1ST-LINE THERAPY; INITIAL THERAPY Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13173