Universität zu Köln

Benton, Matthew Alan, Frey, Nadine, da Fonseca, Rodrigo Nunes, von Levetzow, Cornelia, Stappert, Dominik, Hakeemi, Muhammad Salim, Conrads, Kai H., Pechmann, Matthias, Panfilio, Kristen A., Lynch, Jeremy A. and Roth, Siegfried (2019). Fog signaling has diverse roles in epithelial morphogenesis in insects. eLife, 8. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

The Drosophila Fog pathway represents one of the best-understood signaling cascades controlling epithelial morphogenesis. During gastrulation, Fog induces apical cell constrictions that drive the invagination of mesoderm and posterior gut primordia. The cellular mechanisms underlying primordia internalization vary greatly among insects and recent work has suggested that Fog signaling is specific to the fast mode of gastrulation found in some flies. On the contrary, here we show in the beetle Tribolium, whose development is broadly representative for insects, that Fog has multiple morphogenetic functions. It modulates mesoderm internalization and controls a massive posterior infolding involved in gut and extraembryonic development. In addition, Fog signaling affects blastoderm cellularization, primordial germ cell positioning, and cuboidal-to-squamous cell shape transitions in the extraembryonic serosa. Comparative analyses with two other distantly related insect species reveals that Fog's role during cellularization is widely conserved and therefore might represent the ancestral function of the pathway.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Benton, Matthew Alan UNSPECIFIED UNSPECIFIED UNSPECIFIED Frey, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED da Fonseca, Rodrigo Nunes UNSPECIFIED UNSPECIFIED UNSPECIFIED von Levetzow, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Stappert, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Hakeemi, Muhammad Salim UNSPECIFIED UNSPECIFIED UNSPECIFIED Conrads, Kai H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pechmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Panfilio, Kristen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lynch, Jeremy A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132443
DOI:	10.7554/eLife.47346
Journal or Publication Title:	eLife
Volume:	8
Date:	2019
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-SHAPE CHANGES; DORSOVENTRAL AXIS FORMATION; DROSOPHILA GASTRULATION; TRIBOLIUM EMBRYOGENESIS; FOLDED-GASTRULATION; ANCESTRAL ROLE; RHO-GTPASE; PATHWAY; BLASTODERM; GENE Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13244