Universität zu Köln

Schildgen, Verena and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2019). The lonely driver or the orchestra of mutations? How next generation sequencing datasets contradict the concept of single driver checkpoint mutations in solid tumours - NSCLC as a scholarly example. Semin. Cancer Biol., 58. S. 22 - 29. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1096-3650

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Abstract

Driver mutations are considered to be responsible for the majority of cancers and several of those mutations provide targets in order to set up personalized therapies. So far the generally accepted opinion had been that driver mutations occur as stand-alone factors, but novel sequencing technologies induced an essential rethink. Next generation sequencing approaches have shown that double, triple or multiple concurrent mutations could occur within the same tumour and may by interaction influence sensitivity to anticancer drugs and therapy success. This review focusses on this novel concept and discusses the challenges for molecular pathology and laboratory diagnostics while providing putative solutions to overcome the present pitfalls, thereby taking NSCLC as an example.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132931
DOI:	10.1016/j.semcancer.2018.11.005
Journal or Publication Title:	Semin. Cancer Biol.
Volume:	58
Page Range:	S. 22 - 29
Date:	2019
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1096-3650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL LUNG-CANCER; EGFR MUTATIONS; RESISTANCE MUTATION; ALK REARRANGEMENT; PREDICTS RESPONSE; KRAS MUTATION; CRIZOTINIB; RECEPTOR; GEFITINIB; MUTANT Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13293