Balaji, Seshadri, DiLorenzo, Michael P., Fish, Frank A., Etheridge, Susan P., Aziz, Peter F., Russell, Mark W., Tisma, Svjetlana, Pflaumer, Andreas ORCID: 0000-0002-3830-3643, Sreeram, Narayanswami, Kubus, Peter, Law, Ian H., Kantoch, MichalJ, Kertesz, Naomi J., Strieper, Margaret, Erickson, Christopher C., Moore, Jeremy P., Nakano, Stephanie J., Singh, Harinder R., Chang, Philip, Cohen, Mitchell, Fournier, Anne, Ilina, Maria, V, Smith, Richard T., Zimmerman, Frank, Horndasch, Michaela, Li, Walter, Batra, Anjan, Liberman, Leonardo, Hamilton, Robert, Janson, Christopher M., Sanatani, Shubhayan ORCID: 0000-0001-9296-7400, Zeltser, Ilana, McDaniel, George, Blaufox, Andrew D., Garnreiter, Jason M., Katcoff, Hannah and Shah, Maully (2019). Risk factors for lethal arrhythmic events in children and adolescents with hypertrophic cardiomyopathy and an implantable defibrillator: An international multicenter study. Heart Rhythm, 16 (10). S. 1462 - 1468. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1556-3871

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Abstract

BACKGROUND Predictors of risk of lethal arrhythmic events (LAE) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). OBJECTIVE The purpose of this study was to determine predictors of LAE in children with HCM. METHODS A retrospective data collection was performed on 446 children and teenagers 20 years and younger (290 [65%] male; mean age 10.1 +/- 5.7 years) with idiopathic HCM from 35 centers. Patients were classified as group 1 (HCM with LAE) if having a secondary prevention implantable cardioverter-defibrillator (ICD) or primary prevention ICD with appropriate interventions or group 2 (HCM without LAE) if having a primary prevention ICD without appropriate interventions. RESULTS There were 152 children (34%) in group 1 and 294 (66%) in group 2. Risk factors for group 1 by univariate analysis were septal thickness, posterior left ventricular (LV) wall thickness, lower LV outflow gradient, and Q wave > 3 mm in inferior electrocardiographic leads. Factors not associated with LAE were family history of SCD, abnormal blood pressure response to exercise, and ventricular tachycardia on ambulatory electrocardiographic monitoring. Risk factors for SCD by multivariate analysis were age at ICD placement (hazard ratio [HR] 0.9; P = .0025), LV posterior wall thickness z score (HR 1.02; P < .005), and LV outflow gradient < 30 mm Hg (HR 2.0; P < .006). LV posterior wall thickness z score >= 5 was associated with LAE. CONCLUSION Risk factors for LAE appear different in children compared to adults. Conventional adult risk factors were not significant in children. Further prospective studies are needed to improve risk stratification for LAE in children with HCM.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Balaji, SeshadriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DiLorenzo, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fish, Frank A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Etheridge, Susan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aziz, Peter F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, Mark W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tisma, SvjetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pflaumer, AndreasUNSPECIFIEDorcid.org/0000-0002-3830-3643UNSPECIFIED
Sreeram, NarayanswamiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kubus, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Law, Ian H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kantoch, MichalJUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kertesz, Naomi J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strieper, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erickson, Christopher C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moore, Jeremy P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nakano, Stephanie J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singh, Harinder R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen, MitchellUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fournier, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilina, Maria, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Richard T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmerman, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horndasch, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Batra, AnjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liberman, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamilton, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janson, Christopher M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanatani, ShubhayanUNSPECIFIEDorcid.org/0000-0001-9296-7400UNSPECIFIED
Zeltser, IlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McDaniel, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blaufox, Andrew D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garnreiter, Jason M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katcoff, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, MaullyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-132996
DOI: 10.1016/j.hrthm.2019.04.040
Journal or Publication Title: Heart Rhythm
Volume: 16
Number: 10
Page Range: S. 1462 - 1468
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1556-3871
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUDDEN CARDIAC DEATH; CARDIOVASCULAR MAGNETIC-RESONANCE; OUTFLOW TRACT OBSTRUCTION; TERM-FOLLOW-UP; TASK-FORCE; PREVENTION; DIAGNOSIS; STRATIFICATION; EPIDEMIOLOGY; PREDICTORSMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13299

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