Universität zu Köln

Brueggen, Katharina, Dyrba, Martin, Cardenas-Blanco, Arturo, Schneider, Anja ORCID: 0000-0001-9540-8700, Fliessbach, Klaus, Buerger, Katharina, Janowitz, Daniel, Peters, Oliver, Menne, Felix, Priller, Josef, Spruth, Eike, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Vukovich, Ruth, Laske, Christoph, Buchmann, Martina, Wagner, Michael ORCID: 0000-0003-2589-6440, Roeske, Sandra, Spottke, Annika, Rudolph, Janna, Metzger, Coraline D., Kilimann, Ingo, Dobisch, Laura, Dueze, Emrah, Jessen, Frank and Teipel, Stefan J. (2019). Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease based on multicenter diffusion tensor imaging. J. Neurol., 266 (10). S. 2465 - 2475. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Introduction Subjective cognitive decline (SCD) can represent a preclinical stage of Alzheimer's disease. Diffusion tensor imaging (DTI) could aid an early diagnosis, yet only few monocentric DTI studies in SCD have been conducted, reporting heterogeneous results. We investigated microstructural changes in SCD in a larger, multicentric cohort. Methods 271 participants with SCD, mild cognitive impairment (MCI) or Alzheimer's dementia (AD) and healthy controls (CON) were included, recruited prospectively at nine centers of the observational DELCODE study. DTI was acquired using identical protocols. Using voxel-based analyses, we investigated fractional anisotropy (FA), mean diffusivity (MD) and mode (MO) in the white matter (WM). Discrimination accuracy was determined by cross-validated elastic-net penalized regression. Center effects were explored using variance analyses. Results MO and FA were lower in SCD compared to CON in several anterior and posterior WM regions, including the anterior corona radiata, superior and inferior longitudinal fasciculus, cingulum and splenium of the corpus callosum (p < 0.01, uncorrected). MD was higher in the superior and inferior longitudinal fasciculus, cingulum and superior corona radiata (p < 0.01, uncorrected). The cross-validated accuracy for discriminating SCD from CON was 67% (p < 0.01). As expected, the AD and MCI groups had higher MD and lower FA and MO in extensive regions, including the corpus callosum and temporal brain regions. Within these regions, center accounted for 3-15% of the variance. Conclusions DTI revealed subtle WM alterations in SCD that were intermediate between those in MCI and CON and may be useful to detect individuals with an increased risk for AD in clinical studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brueggen, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Dyrba, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Cardenas-Blanco, Arturo UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Janowitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Menne, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Spruth, Eike UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Vukovich, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchmann, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Roeske, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Janna UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, Coraline D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilimann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Dobisch, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Dueze, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133040
DOI:	10.1007/s00415-019-09429-3
Journal or Publication Title:	J. Neurol.
Volume:	266
Number:	10
Page Range:	S. 2465 - 2475
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DTI; HIPPOCAMPAL; MRI; RECOMMENDATIONS; DEMENTIA; MARKERS Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13304