Universität zu Köln

Goerlinger, Klaus, Perez-Ferrer, Antonio, Dirkmann, Daniel, Saner, Fuat, Maegele, Marc, Perez Calatayud, Angel Augusto and Kim, Tae-Yop ORCID: 0000-0003-0806-8969 (2019). The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management. Korean J. Anesthesiol., 72 (4). S. 297 - 323. SEOUL: KOREAN SOC ANESTHESIOLOGISTS. ISSN 2005-7563

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Abstract

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part of patient blood management (PBM) which is an important concept in improving patient safety. Here, ROTEM testing and hemostatic interventions should be linked by evidence-based, setting-specific algorithms adapted to the specific patient population of the hospitals and the local availability of hemostatic interventions. Accordingly, ROTEM-guided algorithms implement the concept of personalized or precision medicine in perioperative bleeding management ('theranostic' approach). ROTEM-guided PBM has been shown to be effective in reducing bleeding, transfusion requirements, complication rates, and health care costs. Accordingly, several randomized-controlled trials, meta-analyses, and health technology assessments provided evidence that using ROTEM-guided algorithms in bleeding patients resulted in improved patient's safety and outcomes including perioperative morbidity and mortality. However, the implementation of ROTEM in the PBM concept requires adequate technical and interpretation training, education and logistics, as well as interdisciplinary communication and collaboration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goerlinger, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez-Ferrer, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Dirkmann, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Saner, Fuat UNSPECIFIED UNSPECIFIED UNSPECIFIED Maegele, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez Calatayud, Angel Augusto UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Tae-Yop UNSPECIFIED orcid.org/0000-0003-0806-8969 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133768
DOI:	10.4097/kja.19169
Journal or Publication Title:	Korean J. Anesthesiol.
Volume:	72
Number:	4
Page Range:	S. 297 - 323
Date:	2019
Publisher:	KOREAN SOC ANESTHESIOLOGISTS
Place of Publication:	SEOUL
ISSN:	2005-7563
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTHROMBIN COMPLEX CONCENTRATE; PATIENT BLOOD MANAGEMENT; FRESH-FROZEN PLASMA; ORTHOTOPIC LIVER-TRANSPLANTATION; MULTIPLE ELECTRODE AGGREGOMETRY; DAMAGE CONTROL RESUSCITATION; POSTPARTUM HEMORRHAGE OBS2; PEDIATRIC CARDIAC-SURGERY; RED-CELL TRANSFUSION; TRANEXAMIC ACID Multiple languages Anesthesiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13376