Universität zu Köln

Jarczok, Tomasz A., Haase, Robert, Bluschke, Annett, Thiemann, Ulf and Bender, Stephan (2019). Bereitschaftspotential and lateralized readiness potential in children with attention deficit hyperactivity disorder: altered motor system activation and effects of methylphenidate. Eur. Neuropsychopharmacol., 29 (8). S. 960 - 971. AMSTERDAM: ELSEVIER. ISSN 1873-7862

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Abstract

Attention deficit hyperactivity disorder (ADHD) has been linked to abnormal functioning of cortical motor areas such as the supplementary motor area, the premotor cortex and primary motor cortex (MI). The Bereitschaftspotential (BP) and lateralized readiness potential (LRP) are movement-related potentials generated by cortical motor areas. We hypothesized that the BP and LRP would be altered in children with ADHD. A group of 17 children with ADHD (mean age: 11.5 +/- 1.9 years) and a control group of 16 typically developing children (mean age: 12.2 +/- 2.0 years) performed movements at self-chosen irregular intervals while a 64-channel DC-EEG was registered. BP and LRP were calculated from the EEG. The ADHD group had significantly lower and on average positive BP amplitudes at Cz. In agreement with age-dependent maturation effects the LRP had a positive polarity in both groups, but lower amplitudes were found in the ADHD group without medication. The control group showed a mid-central negativity and a positivity over motor areas contra-lateral to the side of movement, whereas no negativity over Cz and a more diffuse positivity was found in the ADHD group. LRP group differences diminished after MPH administration as indicated by an interaction between group and time of measurement/medication. The cortical motor system shows altered functioning during movement preparation and initiation in children affected by ADHD. Positive Bereitschaftspotential polarities may represent delayed cortical maturation. Group differences of LRP were pharmacologically modulated by the catecholaminergic agent MPH. (C) 2019 Elsevier B.V. and ECNP. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jarczok, Tomasz A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haase, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bluschke, Annett UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiemann, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133837
DOI:	10.1016/j.euroneuro.2019.05.003
Journal or Publication Title:	Eur. Neuropsychopharmacol.
Volume:	29
Number:	8
Page Range:	S. 960 - 971
Date:	2019
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-7862
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOVEMENT-RELATED POTENTIALS; DEFICIT/HYPERACTIVITY DISORDER; VOLUNTARY MOVEMENT; CORTICAL POTENTIALS; RESPONSE ACTIVATION; BRAIN-DEVELOPMENT; YOUNG-CHILDREN; ADHD; AREA; ADULTS Multiple languages Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13383