Universität zu Köln

Hoffmann, Manuela A., Wieler, Helmut J., Baues, Christian, Kuntz, Nicholas J., Richardsen, Ines and Schreckenberger, Mathias (2019). The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer. Urology, 130. S. 1 - 13. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1527-9995

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Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (CaP). PSMA-expression correlates with higher serum levels of prostatespecific antigen (PSA) and a higher Gleason score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). This article reviews the literature pertaining to various new imaging technologies for the management of CaP. PSMA positron emission tomography/computed tomography appears to be an excellent diagnostic tool, that may drastically impact the management of a large number of patients with primary and recurrent CaP. (C) 2019 Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffmann, Manuela A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieler, Helmut J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baues, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuntz, Nicholas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Richardsen, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreckenberger, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133953
DOI:	10.1016/j.urology.2019.04.004
Journal or Publication Title:	Urology
Volume:	130
Page Range:	S. 1 - 13
Date:	2019
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1527-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GA-68-LABELED PSMA LIGAND; RADICAL PROSTATECTOMY; MEMBRANE ANTIGEN; BIOCHEMICAL RECURRENCE; GA-68-PSMA-11 PET/CT; RADIATION-DOSIMETRY; DIAGNOSTIC-VALUE; GRADING SYSTEM; GLEASON SCORE; HBED-CC Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13395