Universität zu Köln

Rink, Svenja, Bendella, Habib, Akkin, Salih Murat, Manthou, Marilena, Grosheva, Maria and Angelov, Doychin N. (2019). Experimental Studies on Facial Nerve Regeneration. Anat. Rec., 302 (8). S. 1287 - 1304. HOBOKEN: WILEY. ISSN 1932-8494

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Abstract

Insufficient recovery after injury of a peripheral motor nerve is due to (1) inappropriate pathfinding as a result of axonal regrowth to inappropriate targets, (2) excessive collateral axonal branching at the lesion site, and (3) polyinnervation of the neuromuscular junctions (NMJs). The rat facial nerve model is often used because of its simple and reliable readout to measure recovery of function (vibrissal whisking). Over the last decades scientists have concentrated their efforts to combat mostly NMJ polyinnervation, because it turned out to be very difficult to reduce collateral axonal branching and impossible to navigate thousands of axons toward the original fascicles. In the past, several groups of scientists concentrated their efforts to reduce the activity-dependent polyinnervation of NMJs by electrical stimulation of the muscles (square 0.1 msec pulses at 5 Hz). The results showed no recovery of functions and a severe reduction in the number of innervated NMJs to approximately one fifth of those observed in intact animals. More recent experiments, however, have shown that motor recovery improved significantly following mechanical stimulation of the denervated facial muscles (vibrissal and orbicularis oculi) and that restored functions could invariably be linked to reduced polyinnervation at the NMJ while the number of innervated NMJ remained the same. These results suggest that clinically feasible and effective therapies could be developed and tested in the near future. Anat Rec, 302:1287-1303, 2019. (c) 2019 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Akkin, Salih Murat UNSPECIFIED UNSPECIFIED UNSPECIFIED Manthou, Marilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Grosheva, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133963
DOI:	10.1002/ar.24123
Journal or Publication Title:	Anat. Rec.
Volume:	302
Number:	8
Page Range:	S. 1287 - 1304
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1932-8494
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MARROW STROMAL CELLS; ELECTRICAL-STIMULATION PROMOTES; MESENCHYMAL STEM-CELLS; OLFACTORY ENSHEATHING CELLS; IMPROVES FUNCTIONAL RECOVERY; CILIARY NEUROTROPHIC FACTOR; ORBICULARIS OCULI MUSCLE; RAT SPINAL-CORD; SCHWANN-CELLS; GROWTH CONE Multiple languages Anatomy & Morphology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13396