Universität zu Köln

Herholz, Marija, Cepeda, Estela, Baumann, Linda, Kukat, Alexandra, Hermeling, Johannes, Maciej, Sarah, Szczepanowska, Karolina, Pavlenko, Victor, Frommolt, Peter ORCID: 0000-0002-1966-8014 and Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517 (2019). KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Most manipulations that extend lifespan also increase resistance to various stress factors and environmental cues in a range of animals from yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Kruppel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. A redox-regulated KLF-1 activation and transfer to the nucleus coincides with the peak of somatic mitochondrial biogenesis that occurs around a transition from larval stage L3 to D1. We further show that KLF-1 activates genes involved in the xenobiotic detoxification programme and identified cytochrome P450 oxidases, the KLF-1 main effectors, as longevity-assurance factors of mitochondrial mutants. Collectively, these findings underline the importance of the xenobiotic detoxification in the mitohormetic, longevity assurance pathway and identify KLF-1 as a central factor in orchestrating this response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herholz, Marija UNSPECIFIED UNSPECIFIED UNSPECIFIED Cepeda, Estela UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukat, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermeling, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Maciej, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Szczepanowska, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlenko, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Frommolt, Peter UNSPECIFIED orcid.org/0000-0002-1966-8014 UNSPECIFIED Trifunovic, Aleksandra UNSPECIFIED orcid.org/0000-0002-5472-3517 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-134701
DOI:	10.1038/s41467-019-11275-w
Journal or Publication Title:	Nat. Commun.
Volume:	10
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-SPAN; SUPEROXIDE-PRODUCTION; ELECTRON-TRANSPORT; FUNCTIONAL-ANALYSIS; OXIDATIVE STRESS; C-ELEGANS; EXPRESSION; DNA; CYTOCHROME-P450; METABOLISM Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13470