Universität zu Köln

Yilmaz, Rezzak ORCID: 0000-0002-0367-4102, Hopfner, Franziska ORCID: 0000-0001-6524-0281, van Eimeren, Thilo and Berg, Daniela (2019). Biomarkers of Parkinson's disease: 20years later. J. Neural Transm., 126 (7). S. 803 - 814. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Despite intensive effort, biomarker research for the detection of prodromal stage, diagnosis and progression of Parkinson's disease (PD) falls short of expectations. This article reviews the attempts in the last 20years to find a biomarker, addresses challenges along the biomarker search and suggests the steps that should be taken to overcome these challenges. Although several biomarkers are currently available, none of them is specific enough for diagnosis, prediction of future PD or disease progression. The main reason for the failure finding a strong biomarker seems to be drastic heterogeneity of PD, which exhibits itself in all domains; from the clinic to pathophysiology or genetics. The diversity in patient selection, assessment methods or outcomes in biomarker studies also limit the interpretation and generalizability of the data. In search of a reliable biomarker, consideration of novel approaches encompassing individual demographic, clinical, genetic, epigenetic and environmental differences, employment of strategies enabling marker combinations, designing multicenter studies with compatible assessment methods, integration of data from preclinical domains and utilization of novel technology-based assessments are necessary.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yilmaz, Rezzak UNSPECIFIED orcid.org/0000-0002-0367-4102 UNSPECIFIED Hopfner, Franziska UNSPECIFIED orcid.org/0000-0001-6524-0281 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-136217
DOI:	10.1007/s00702-019-02001-3
Journal or Publication Title:	J. Neural Transm.
Volume:	126
Number:	7
Page Range:	S. 803 - 814
Date:	2019
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MDS RESEARCH CRITERIA; NEUROFILAMENT LIGHT-CHAIN; CEREBROSPINAL-FLUID; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; DNA METHYLATION; CSF; PROGRESSION; MARKERS; ASSOCIATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13621