Universität zu Köln

Riedel, Richard, Michels, Sebastian, Heydt, Carina, Siemanowski, Janna, Kobe, Carsten, Bunck, Anne, Schaefer, Stephan, Fischer, Rieke N., Scheffler, Matthias, Abdulla, Diana S. Y., Nogova, Lucia, Koleczko, Sophia, Merkelbach-Bruse, Sabine, Buettner, Reinhard and Wolf, Juergen (2019). Acquired KRAS mutation and loss of low-level MET amplification after durable response to crizotinib in a patient with lung adenocarcinoma. Lung Cancer, 133. S. 20 - 23. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8332

Full text not available from this repository.

Abstract

Objectives: Resistance to tyrosine kinase inhibitor (TKI) therapy occurs inevitably in lung cancer patients with targetable genetic alterations. MET amplification has found to be an oncogenic driver in lung cancer with several reports showing response to MET TKI especially in cases with high-level amplification. Materials and methods: We report the case of a patient with lung adenocarcinoma harbouring low-level MET amplification and strong MET expression who was treated with crizotinib. Results: The patient developed a durable response to crizotinib. A KRAS mutation and loss of MET amplification was found in a new lesion at time of progression as a potential mechanism of acquired resistance. Conclusion: MET amplification is a continuous biomarker with responses to MET TM observed even in patients with low-level amplification. KRAS mutations may act as a resistance mechanism to MET inhibition in MET dependent lung cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Riedel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Heydt, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Siemanowski, Janna UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Rieke N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheffler, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdulla, Diana S. Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nogova, Lucia UNSPECIFIED UNSPECIFIED UNSPECIFIED Koleczko, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-136480
DOI:	10.1016/j.lungcan.2019.05.006
Journal or Publication Title:	Lung Cancer
Volume:	133
Page Range:	S. 20 - 23
Date:	2019
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESISTANCE; INHIBITOR Multiple languages Oncology; Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13648