Goettler, Jens, Preibisch, Christine ORCID: 0000-0003-4067-1928, Riederer, Isabelle, Pasquini, Lorenzo ORCID: 0000-0002-7899-7061, Alexopoulos, Panagiotis, Bohn, Karl Peter, Yakushev, Igor, Beller, Ebba ORCID: 0000-0002-5268-151X, Kaczmarz, Stephan, Zimmer, Claus, Grimmer, Timo, Drzezga, Alexander and Sorg, Christian (2019). Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J. Cereb. Blood Flow Metab., 39 (7). S. 1314 - 1326. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1559-7016

Full text not available from this repository.

Abstract

Functional connectivity of blood oxygenation level dependent signal fluctuations (BOLD-FC) is decreased in Alzheimer's disease (AD), and suggested to reflect reduced coherence in neural population activity; however, as both neuronal and vascular-hemodynamic processes underlie BOLD signals, impaired perfusion might also contribute to reduced BOLD-FC; 42 AD patients and 27 controls underwent simultaneous PET/MR imaging. Resting-state functional MRI assessed BOLD co-activity to quantify BOLD-FC, pulsed arterial spin labeling (pASL) assessed cerebral blood flow (CBF) as proxy for vascular hemodynamics, and F-18-fluorodeoxyglucose PET assessed glucose metabolism (GluMet) to index neuronal activity. Patients' BOLD-FC, CBF, and GluMet were reduced within the same precuneal parietal regions. BOLD-FC was positively associated with mean CBF, specifically in patients and controlled for GluMet levels, suggesting that BOLD-FC reductions correlate with pASL-derived hypoperfusion in AD, independently from F-18-fluorodeoxyglucose PET-derived hypometabolism. Data indicate that impaired vascular hemodynamic processes contribute to reduced BOLD connectivity in AD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Goettler, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preibisch, ChristineUNSPECIFIEDorcid.org/0000-0003-4067-1928UNSPECIFIED
Riederer, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pasquini, LorenzoUNSPECIFIEDorcid.org/0000-0002-7899-7061UNSPECIFIED
Alexopoulos, PanagiotisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohn, Karl PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakushev, IgorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beller, EbbaUNSPECIFIEDorcid.org/0000-0002-5268-151XUNSPECIFIED
Kaczmarz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmer, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimmer, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-136584
DOI: 10.1177/0271678X18759182
Journal or Publication Title: J. Cereb. Blood Flow Metab.
Volume: 39
Number: 7
Page Range: S. 1314 - 1326
Date: 2019
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1559-7016
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITRON-EMISSION-TOMOGRAPHY; DEFAULT-MODE NETWORK; AMYLOID-BETA; INTRINSIC CONNECTIVITY; FDG-PET; STATE; DYSFUNCTION; DEMENTIA; MICE; MRIMultiple languages
Endocrinology & Metabolism; Hematology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13658

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item