Azukaitis, Karolis, Ju, Wenjun, Kirchner, Marietta, Nair, Viji, Smith, Michelle, Fang, Zhiyin, Thurn-Valsassina, Daniela, Bayazit, Aysun, Niemirska, Anna, Canpolat, Nur ORCID: 0000-0002-3420-9756, Bulut, Ipek Kaplan, Yalcinkaya, Fatos, Paripovic, Dusan, Harambat, Jerome ORCID: 0000-0003-2016-120X, Cakar, Nilgun ORCID: 0000-0002-1853-0101, Alpay, Harika, Lugani, Francesca, Mencarelli, Francesca, Civilibal, Mahmut, Erdogan, Hakan, Gellermann, Jutta, Vidal, Enrico, Tabel, Yilmaz, Gimpel, Charlotte, Ertan, Pelin, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Arbeiter, Klaus, Rosales, Alejandra, Dusek, Jiri, Zaloszyc, Ariane, Querfeld, Uwe, Gellermann, Jutta, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Melk, Anette, Thurn-Valassina, Daniela, Haffner, Dieter, Schaefer, Franz, Gimpel, Charlotte, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Wigger, Marianne, Testa, Sara, Murer, Luisa, Matteucci, Chiara, Jankauskiene, Augustina, Azukaitis, Karolis, Drozdz, Dorota, Lugani, Francesca, Zurowska, Aleksandra, Zaniew, Marcin, Litwin, Mieczyslaw ORCID: 0000-0002-5241-2483, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Paripovic, Dusan, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Bayazit, Aysun, Duzova, Ali, Bilginer, Yelda, Caliskan, Salim ORCID: 0000-0002-3316-8032, Canpolat, Nur ORCID: 0000-0002-3420-9756, Civilibal, Mahmut, Mir, Sevgi, Soezeri, Betul, Kranz, Brigitta, Mencarelli, Francesca, Dorn, Brigitte, Yalcinkaya, Fatos, Baskin, Esra, Cakar, Nilgun ORCID: 0000-0002-1853-0101, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Alpay, Harika, Shroff, Rukshana, Rachin, Bruno, Harambat, Jerome ORCID: 0000-0003-2016-120X, Szczepanska, Maria ORCID: 0000-0002-6772-1983, Erdogan, Hakan, Donmez, Osman, Balat, Ayse, Aksu, Nejat, Tabel, Yilmaz, Ertan, Pelin, Yilmaz, Ebru, Anarat, Ali, Bakkaloglu, Aysin, Ozaltin, Fatih, Peco-Antic, Amira, Querfeld, Uwe, Gellermann, Jutta, Sallay, Peter, Drozdz, Dorota, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Wuehl, Elke, Hadtstein, Charlotte, Mehls, Otto, Schaefer, Franz, Emre, Sevinc, Caliskan, Salim ORCID: 0000-0002-3316-8032, Mir, Sevgi, Wygoda, Simone, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Klaus, Guenter, Ardissino, Gianluigi, Testa, Sara, Montini, Giovanni ORCID: 0000-0002-7350-4475, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Dusek, Jiri, Matteucci, Chiara, Picca, Stefano, Wigger, Marianne, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Fydryk, Janusz, Urasinski, Tomasz, Coppo, Rosanna, Peruzzi, Licia, Arbeiter, Klaus, Jankauskiene, Augustina, Grenda, Ryszard, Litwin, Mieczyslaw ORCID: 0000-0002-5241-2483 and Neuhaus, Thomas J. (2019). Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children. Kidney Int., 96 (1). S. 214 - 222. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1755

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Abstract

Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Azukaitis, KarolisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ju, WenjunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirchner, MariettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nair, VijiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, MichelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fang, ZhiyinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurn-Valsassina, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayazit, AysunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemirska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canpolat, NurUNSPECIFIEDorcid.org/0000-0002-3420-9756UNSPECIFIED
Bulut, Ipek KaplanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalcinkaya, FatosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paripovic, DusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harambat, JeromeUNSPECIFIEDorcid.org/0000-0003-2016-120XUNSPECIFIED
Cakar, NilgunUNSPECIFIEDorcid.org/0000-0002-1853-0101UNSPECIFIED
Alpay, HarikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lugani, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mencarelli, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Civilibal, MahmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erdogan, HakanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gellermann, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabel, YilmazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gimpel, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertan, PelinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yavascan, OnderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melk, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuehl, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretzler, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arbeiter, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosales, AlejandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dusek, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaloszyc, ArianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gellermann, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liebau, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muschiol, EvelinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buescher, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oh, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melk, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurn-Valassina, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haffner, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gimpel, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wygoda, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeck, NikolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wigger, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Testa, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murer, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matteucci, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jankauskiene, AugustinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azukaitis, KarolisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drozdz, DorotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lugani, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zurowska, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaniew, MarcinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litwin, MieczyslawUNSPECIFIEDorcid.org/0000-0002-5241-2483UNSPECIFIED
Nimierska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teixeira, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peco-Antic, AmiraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paripovic, DusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laube, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dali, Cocuk Nefrolojisi BilimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anarat, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayazit, AysunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzova, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilginer, YeldaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caliskan, SalimUNSPECIFIEDorcid.org/0000-0002-3316-8032UNSPECIFIED
Canpolat, NurUNSPECIFIEDorcid.org/0000-0002-3420-9756UNSPECIFIED
Civilibal, MahmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mir, SevgiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soezeri, BetulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, BrigittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mencarelli, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorn, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalcinkaya, FatosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baskin, EsraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cakar, NilgunUNSPECIFIEDorcid.org/0000-0002-1853-0101UNSPECIFIED
Soylemezoglu, OguzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emre, SevincUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Candan, CengizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiyak, AyselUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozcelik, GulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpay, HarikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shroff, RukshanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rachin, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harambat, JeromeUNSPECIFIEDorcid.org/0000-0003-2016-120XUNSPECIFIED
Szczepanska, MariaUNSPECIFIEDorcid.org/0000-0002-6772-1983UNSPECIFIED
Erdogan, HakanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donmez, OsmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balat, AyseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aksu, NejatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabel, YilmazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertan, PelinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yilmaz, EbruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anarat, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakkaloglu, AysinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozaltin, FatihUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peco-Antic, AmiraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gellermann, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sallay, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drozdz, DorotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonzel, Klaus-EugenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wingen, Anna-MargreteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urowska, Aleksandra Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balasz, IrenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trivelli, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perfumo, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Wiefel, Dirk-ErhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Offner, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enke, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuehl, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hadtstein, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehls, OttoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emre, SevincUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caliskan, SalimUNSPECIFIEDorcid.org/0000-0002-3316-8032UNSPECIFIED
Mir, SevgiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wygoda, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hohbach-Hohenfellner, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeck, NickolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaus, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ardissino, GianluigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Testa, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montini, GiovanniUNSPECIFIEDorcid.org/0000-0002-7350-4475UNSPECIFIED
Charbit, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niaudet, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Afonso, Alberto CaldasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandes-Teixeira, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dusek, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matteucci, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Picca, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wigger, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, Ulla B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Celsi, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischbach, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terzic, JoelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fydryk, JanuszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urasinski, TomaszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coppo, RosannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peruzzi, LiciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arbeiter, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jankauskiene, AugustinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grenda, RyszardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litwin, MieczyslawUNSPECIFIEDorcid.org/0000-0002-5241-2483UNSPECIFIED
Neuhaus, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-136903
DOI: 10.1016/j.kint.2019.01.035
Journal or Publication Title: Kidney Int.
Volume: 96
Number: 1
Page Range: S. 214 - 222
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1523-1755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RISK-FACTORS; YOUNG-ADULTS; EXCRETION; ROLES; EGFMultiple languages
Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13690

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