Universität zu Köln

van Rijssen, Thomas J., van Dijk, Elon H. C., Scholz, Paula, Breukink, Myrte B., Blanco-Garavito, Rocio, Souied, Eric H., MacLaren, Robert E., Querques, Giuseppe, Fauser, Sascha, Hoyng, Carel B., Downes, Susan M. and Boon, Camiel J. F. (2019). Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage. Graefes Arch. Clin. Exp. Ophthalmol., 257 (7). S. 1419 - 1426. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

PurposeTo describe the characteristics and potential differences between focal and diffuse phenotypes of untreated chronic central serous chorioretinopathy (cCSC).MethodsFor this study, patients were divided in two groups. Focal leakage was defined as 1 hot spot of leakage, whereas diffuse leakage was defined as either >1 hot spot or a larger area of widespread leakage on FA. Clinical characteristics were assessed at presentation. After Bonferroni correction, P values <0.00125 were deemed statistically significant.ResultsThe focal leakage group included 68 eyes (53 males), and the diffuse leakage group included 105 eyes (88 males). Mean best-corrected visual acuity (BCVA) was 77.18.1 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the focal group and 76.0 +/- 9.6 ETDRS letters in the diffuse group (p=0.440). In the focal group, mean age was 46.9 +/- 8.8years, whereas this was 49.7 +/- 8.3years in the diffuse group (p=0.033). Mean central foveal thickness was 107.1 +/- 21.3m in the focal group and 106.2 +/- 27.3m in the diffuse group (p=0.818). Mean choroidal thickness was 407.5 +/- 114.8m in the focal group and 419.1 +/- 113.9m in the diffuse group (p=0.578). In the focal group, subretinal fluid was present in the fellow eye in 16% of the patients, as compared to 29% in the diffuse group (p=0.067).Conclusions In untreated cCSC patients with focal or diffuse leakage on FA, no marked differences in clinical characteristics were found. Extensive choroidal abnormalities may be present in both groups, which are presumed to lie at the basis of the development of cCSC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Rijssen, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Paula UNSPECIFIED UNSPECIFIED UNSPECIFIED Breukink, Myrte B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blanco-Garavito, Rocio UNSPECIFIED UNSPECIFIED UNSPECIFIED Souied, Eric H. UNSPECIFIED UNSPECIFIED UNSPECIFIED MacLaren, Robert E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Querques, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Downes, Susan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137017
DOI:	10.1007/s00417-019-04333-y
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	257
Number:	7
Page Range:	S. 1419 - 1426
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDOCYANINE GREEN ANGIOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY; CLINICAL CHARACTERISTICS; PHOTODYNAMIC THERAPY; VIDEOANGIOGRAPHY; BANDS Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13701