Universität zu Köln

Streckmann, Fiona, Lehmann, H. C., Balke, M., Schenk, A., Oberste, M., Heller, A., Schuerhoerster, A., Elter, T., Bloch, W. and Baumann, F. T. (2019). Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathya randomized controlled pilot trial. Support. Care Cancer, 27 (7). S. 2471 - 2479. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients' quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant symptoms. We conducted a prospective, four-armed, randomized, controlled trial, to evaluate the effects of sensorimotor training (SMT) and whole-body vibration training (WBV) on patients with CIPN. Participants (N=40) were randomized to either one of two intervention groups (SMT N=10 or WBV N=10) or oncological control group (N=10) and matched by gender and age with a healthy control (N=10). The intervention groups exercised twice a week for 6weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR P=.017 and PSR P=.020), peripheral deep sensitivity (P=.010), and pain (P=.043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (P=.075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (P=.054) and dyspnea (P=.054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).Registration: DRKS00013027

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Streckmann, Fiona UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Balke, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberste, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heller, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuerhoerster, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, F. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137202
DOI:	10.1007/s00520-018-4531-4
Journal or Publication Title:	Support. Care Cancer
Volume:	27
Number:	7
Page Range:	S. 2471 - 2479
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; EXERCISE; BALANCE; PROGRAM; ADAPTATIONS; PREVENTION; MANAGEMENT Multiple languages Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13720